Antimicrobial cytotoxicity and phytochemical activities of Spilanthes acmella

Authors

  • S Ahmed Analytical Research Division, BCSIR Laboratories Dhaka, Dhaka-1205
  • A Rahman Department of Chemistry, University of Dhaka, Dhaka-1000
  • T Muslim Department of Chemistry, University of Dhaka, Dhaka-1000
  • MH Sohrab Department of Chemistry, University of Dhaka, Dhaka-1000
  • MA Akbor Department of Chemistry, University of Dhaka, Dhaka-1000
  • S Siraj Department of Chemistry, University of Dhaka, Dhaka-1000
  • N Sultana Department of Chemistry, University of Dhaka, Dhaka-1000
  • MA Al-Mansur Department of Chemistry, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bjsir.v47i4.14073

Keywords:

Antimicrobial activity, Bioassay, Extraction and isolation, Structural elucidation

Abstract

?-Sitosterone was isolated from the dichloromethane extract of the leaves of Spilanthes acmella. Stigmasterol was isolated from the petroleum and dichloromethane extract respectively. The structures of compounds were elucidated on the basis of spectral analysis as well as by comparison with available literature data. Pet-ether & DCM extract and two column fractions of DCM and one pure compound were subjected to antimicrobial screening & brine shrimp lethality. All of the fractions showed moderate to strong inhibitory activity to microbial growth. On the other hand, the pet ether extract and pure compound (stigmasterol) showed strongest cytotoxicity having LC50 1.2 ?g/mL and 2.02 ?g/mL respectively.

Bangladesh J. Sci. Ind. Res. 47(4), 437-440, 2012

DOI: http://dx.doi.org/10.3329/bjsir.v47i4.14073

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Published

2013-03-06

How to Cite

Ahmed, S., Rahman, A., Muslim, T., Sohrab, M., Akbor, M., Siraj, S., Sultana, N., & Al-Mansur, M. (2013). Antimicrobial cytotoxicity and phytochemical activities of Spilanthes acmella. Bangladesh Journal of Scientific and Industrial Research, 47(4), 437–440. https://doi.org/10.3329/bjsir.v47i4.14073

Issue

Vol. 47 No. 4 (2012)

Section

Articles

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