In vitro evaluation of Ciprofloxacin Hydrochloride

Authors

  • M Jaman Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • AA Chowdhury Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000
  • AA Rana Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • SM Masum Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • T Ferdous Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • MA Rashid Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000
  • MM Karim Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bjsir.v50i4.25833

Keywords:

Ciprofloxacin HCl, UV visible spectroscopy, Disintegration test, Dissolution test

Abstract

The in vitro evaluation of the physical characteristics of the pharmaceutical products ensures their quality as well as bioavailability and impart optimum therapeutic activity. Ciprofloxacin HCl, a widely used antibiotic to treat different types of bacterial infections, was chosen for this in vitro comparative study of different pharmaceutical company. The present study compared the content uniformity, weight variation, hardness, friability, thickness, diameter, disintegration and dissolution ability of five brands of ciprofloxacin HCl tablets marketed in Bangladesh to confirm whether they follow USP guidelines. All five brands of ciprofloxacin HCl tested meet the specification of the USP for content uniformity, weight variation, hardness, friability, thickness, diameter, disintegration and dissolution. The amount of active ciprofloxacin HCl varies from 244.46 mg to 248.46 mg among the products. The average hardness and friability of the products varies 73.9 N to 77.6 N and 0.013% to 0.031%, respectively. All the brands had shown disintegration time 5 to 8 minutes while they showed 80 to 95 % release of active ingredient within 30 minutes in dissolution testing. This may confirm the absorption of the drug from gastrointestinal tract for optimum therapeutic effect.

Bangladesh J. Sci. Ind. Res. 50(4), 251-256, 2015

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Author Biography

M Jaman, Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000



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Published

2015-12-11

How to Cite

Jaman, M., Chowdhury, A., Rana, A., Masum, S., Ferdous, T., Rashid, M., & Karim, M. (2015). In vitro evaluation of Ciprofloxacin Hydrochloride. Bangladesh Journal of Scientific and Industrial Research, 50(4), 251–256. https://doi.org/10.3329/bjsir.v50i4.25833

Issue

Vol. 50 No. 4 (2015)

Section

Articles

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