Synthesis of potential pharmaceutically active dihydropyrimidine-2-oxo and their 2-thio analogues

Authors

  • ME Halim Department of Chemistry, University of Dhaka, Dhaka-1000
  • K Akhter Department of Chemistry, University of Dhaka, Dhaka-1000
  • M Hasan Department of Chemistry, University of Dhaka, Dhaka-1000
  • MM Rahman Department of Chemistry, Jagannath University, Dhaka-1100
  • UKR Romman Department of Chemistry, University of Dhaka, Dhaka-1000
  • MG Ahmed Department of Chemistry, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bjsir.v53i4.39198

Keywords:

Cyclocondensation, Aldehydes, β - dicarbonyl, Urea and thiourea

Abstract

The Biginelli one - pot three-component cyclocondensation was applied to prepare 3, 4 - dihydropyrimidin - 2 (1H) – ones from aldehydes, β-dicarbonyl compounds and urea (or thiourea) using ZnCl2 as a catalyst. The method offers several advantages including short reaction times and easy experimental work up procedures.

Bangladesh J. Sci. Ind. Res.53(4), 327-332, 2018

Downloads

Download data is not yet available.
Abstract
34
PDF
39

Downloads

Published

2018-12-09

How to Cite

Halim, M., Akhter, K., Hasan, M., Rahman, M., Romman, U., & Ahmed, M. (2018). Synthesis of potential pharmaceutically active dihydropyrimidine-2-oxo and their 2-thio analogues. Bangladesh Journal of Scientific and Industrial Research, 53(4), 327–332. https://doi.org/10.3329/bjsir.v53i4.39198

Issue

Vol. 53 No. 4 (2018)

Section

Short Communications

License

Bangladesh Council of Scientific and Industrial Research (BCSIR) holds the copyright to all contents published in Bangladesh Journal of Scientific and Industrial Research (BJSIR). A copyright transfer form should be signed by the author(s) and be returned to BJSIR.

The entire contents of the BJSIR are protected under Bangladesh Council of Scientific and Industrial Research (BCSIR) copyrights.

Creative Commons Licence
BJSIR is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC) Creative Commons Attribution-NonCommercial 4.0 International License which allows others remix, tweak, and build upon the articles non-commercially, and although their new works must also acknowledge and be non-commercial, they don’t have to license their derivative works on the same terms.