Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity

Authors

  • K Akhter Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • K Jahan Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • ME Halim Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • S Shefa Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • S Rifat Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • KR Khan Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • SM Ahmed Department of Chemistry, American International University-Bangladesh, Khilkhet, Dhaka-1229, Bangladesh
  • UKR Romman Department of Chemistry, American International University-Bangladesh, Khilkhet, Dhaka-1229, Bangladesh

DOI:

https://doi.org/10.3329/bjsir.v54i1.40730

Keywords:

Nickel nitrate hexahydrate; 1-Phenyl thiourea; Aldehydes; Ethyl acetoacetate; Biginelli reaction; Antimicrobial activity

Abstract

We report herein the use of nickel nitrate hexahydrate [Ni(NO3)2.6H2O] as a new catalyst for the one-pot Biginelli like reaction coupling of 1-phenyl thiourea, ethyl acetoacetate and aromatic aldehydes to afford the corresponding 1-phenyl-3,4-dihydropyrimidin-2(1H)-thiones under solvent free condition to avoid the usage of hazardous organic solvents. The synthesized compounds were evaluated for their antimicrobial activity by KIRBY-BAUER disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity.

Bangladesh J. Sci. Ind. Res.54(1), 47-54, 2019

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Published

2019-03-25

How to Cite

Akhter, K., Jahan, K., Halim, M., Shefa, S., Rifat, S., Khan, K., Ahmed, S., & Romman, U. (2019). Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity. Bangladesh Journal of Scientific and Industrial Research, 54(1), 47–54. https://doi.org/10.3329/bjsir.v54i1.40730

Issue

Vol. 54 No. 1 (2019)

Section

Articles

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