Application of Statistical Experimental Design to Benzylation of <i>p</i>-Chlorophenol

Authors

  • Shams Tania Afroza Islam Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • Manoranjan Saha Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • Dipti Saha Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • Mohammad Ismail Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • Mirza Galib Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000
  • Nashid Sharif Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bjsir.v45i2.5706

Keywords:

p-Chlorophenol, Benzyl alcohol, Perchloric acid, 2-benzyl-4-chlorophenol, Experimental design

Abstract

A 23 Yates pattern experimental design was used to develop a mathematical model for the benzylation of p-chlorophenol with benzyl alcohol in the presence of perchloric acid as catalyst. A set of trials was planned with two replicates and the centre point trial with 4 replicates according to the design. The critical response was the yield of 2-benzyl-4-chlorophenol. Main effects as well as two- and three- factor interaction effects were statistically significant. The highest experimental yield was 91.6%. The experimental settings were 130°C, molar ratio of p-chlorophenol to benzyl alcohol 4:1, amount of 60% perchloric acid 5% by wt. of p-chlorophenol, addition time 2 h and stirring time 1 h. The difference between the experimental and predicted yields did not exceed 0.04%.

Key words: p-Chlorophenol; Benzyl alcohol; Perchloric acid; 2-benzyl-4-chlorophenol; Experimental design

DOI: 10.3329/bjsir.v45i2.5706

Bangladesh J. Sci. Ind. Res. 45(2), 105-110, 2010

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How to Cite

Islam, S. T. A., Saha, M., Saha, D., Ismail, M., Galib, M., & Sharif, N. (2010). Application of Statistical Experimental Design to Benzylation of <i>p</i>-Chlorophenol. Bangladesh Journal of Scientific and Industrial Research, 45(2), 105–110. https://doi.org/10.3329/bjsir.v45i2.5706

Issue

Vol. 45 No. 2 (2010)

Section

Articles

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