Drug Complexation and Formulation of a Buccal Tablet

Authors

  • Rajashree Hirlekar Department of Pharmaceutics, Bharati Vidyapeeth's College of Pharmacy, Mumbai
  • Vilasrao Kadam Department of Pharmaceutics, Bharati Vidyapeeth's College of Pharmacy, Mumbai

DOI:

https://doi.org/10.3329/bjsir.v45i2.5709

Keywords:

Carvedilol, Beta-Cyclodextrin, Complexation, Dissolution, Characterization, Permeation

Abstract

In the present work use of Beta-Cyclodextrin for inclusion of Carvedilol, an antihypertensive drug with poor solubility and high first pass metabolism was studied, in order to improve its dissolution rate. The complex prepared by kneading method was characterized by Differential Scanning Calorimetry, Fourier Transformation Infra Red Spectroscopy and X-Ray Diffractometry along with the plain drug and physical mixture. The drug so complexed was incorporated into a buccal dosage form to by pass first pass metabolism to improve its bioavailability. The buccal tablets containing complex showed reasonable mucoadhesive strength. The dissolution and permeability across pig buccal mucosa were improved in case of tablets containing the complex as compared to plain drug tablet.

Key words: Carvedilol; Beta-Cyclodextrin; Complexation; Dissolution; Characterization; Permeation.

DOI: 10.3329/bjsir.v45i2.5709

Bangladesh J. Sci. Ind. Res. 45(2), 123-128, 2010

Downloads

Download data is not yet available.
Abstract
189
PDF
221

Downloads

How to Cite

Hirlekar, R., & Kadam, V. (2010). Drug Complexation and Formulation of a Buccal Tablet. Bangladesh Journal of Scientific and Industrial Research, 45(2), 123–128. https://doi.org/10.3329/bjsir.v45i2.5709

Issue

Vol. 45 No. 2 (2010)

Section

Articles

License

Bangladesh Council of Scientific and Industrial Research (BCSIR) holds the copyright to all contents published in Bangladesh Journal of Scientific and Industrial Research (BJSIR). A copyright transfer form should be signed by the author(s) and be returned to BJSIR.

The entire contents of the BJSIR are protected under Bangladesh Council of Scientific and Industrial Research (BCSIR) copyrights.

Creative Commons Licence
BJSIR is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC) Creative Commons Attribution-NonCommercial 4.0 International License which allows others remix, tweak, and build upon the articles non-commercially, and although their new works must also acknowledge and be non-commercial, they don’t have to license their derivative works on the same terms.