<i>In Vitro</i> Dissolution of Aceclofenac Loaded Hydrophilic Polymer Based Matrix Tablets and its Release Mechanism

Authors

  • M Mesbah Uddin Talukder Department of Pharmacy, The University of Asia pacific, Dhaka
  • Nadia Ahmed Department of Pharmacy, The University of Asia pacific, Dhaka
  • Tasnuva Haque Department of Pharmacy, Stamford University Bangladesh, Dhaka
  • Sadia Afreen Chowdhury Department of Pharmacy, Stamford University Bangladesh, Dhaka

DOI:

https://doi.org/10.3329/bjsir.v45i2.5712

Keywords:

Aceclofenac, Matrix tablets, HPMC, CMC, Physical parameters, Release kinetics

Abstract

Hydrophilic polymers are widely used to prepare sustained release matrix tablets. These polymers showed their sustained action by forming a barrier of thick gel layer around the matrix. Here swelling of the polymer and erosion of matrix plays a major role to control the release of the drug. In this present study the swelling and erosion properties of some hydrophilic polymers were correlated to their sustaining and rate controlling behavior. Matrix tablets containing hydroxypropyl methylcellulose (HPMC K100cps), carboxymethyl cellulose (CMC 50,000 cps) and methocel K15M CR polymers were prepared. The powder mixture was evaluated for their flow properties and the prepared tablets for their physical parameters. Swelling and erosion index of the tablets were carried out in pH 6.8 phosphate buffer and dissolution in 0.1N HCl (2 hours) followed by pH 6.8 phosphate buffer (8 hours) using USP apparatus II (paddle method) at 50 r.p.m. HPMC K100 cps was found to be not as rate retarding as the other two. From the all results it was observed that F-6 (containing 43.243% methocel K15M CR) showed highest swelling and erosion index (740.589% and 12.017% respectively), slowest release rate (24.491% at 8 hours) and highest MDT value (55.401 hours). Finally it can be concluded that increasing the polymer concentration or polymer's viscosity grade, swelling and erosion index increases, release rate decreases and MDT value increases.
 
Key words: Aceclofenac; Matrix tablets; HPMC; CMC; Physical parameters; Release kinetics.

DOI: 10.3329/bjsir.v45i2.5712

Bangladesh J. Sci. Ind. Res. 45(2), 141-150, 2010

Downloads

Download data is not yet available.
Abstract
218
PDF
116

Downloads

How to Cite

Talukder, M. M. U., Ahmed, N., Haque, T., & Chowdhury, S. A. (2010). <i>In Vitro</i> Dissolution of Aceclofenac Loaded Hydrophilic Polymer Based Matrix Tablets and its Release Mechanism. Bangladesh Journal of Scientific and Industrial Research, 45(2), 141–150. https://doi.org/10.3329/bjsir.v45i2.5712

Issue

Vol. 45 No. 2 (2010)

Section

Articles

License

Bangladesh Council of Scientific and Industrial Research (BCSIR) holds the copyright to all contents published in Bangladesh Journal of Scientific and Industrial Research (BJSIR). A copyright transfer form should be signed by the author(s) and be returned to BJSIR.

The entire contents of the BJSIR are protected under Bangladesh Council of Scientific and Industrial Research (BCSIR) copyrights.

Creative Commons Licence
BJSIR is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC) Creative Commons Attribution-NonCommercial 4.0 International License which allows others remix, tweak, and build upon the articles non-commercially, and although their new works must also acknowledge and be non-commercial, they don’t have to license their derivative works on the same terms.