Antioxidant and thrombolytic activities of Crinum asiaticum L.

Authors

  • Md Saiful Islam Pharmaceutical Sciences Research Division, BCSIR Dhaka Laboratories, Bangladesh Council of Scientific and Industrial Research, Dhaka-1205, Bangladesh
  • Sharmin Ahmed Rakhi Department of Pharmacy, United International University, United City, Madani Avenue, Badda, Dhaka 1212, Bangladesh
  • Md Ruhul Kuddus Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • Md Raihan Sarkar Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • Firoj Ahmed Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.5564/bjsir.v59i4.73758

Keywords:

Crinum asiaticum, Antioxidant, Total phenol content, DPPH, Thrombolytic

Abstract

Crinum asiaticum L. is a toxic plant and can be grown as an ornamental plant in Bangladesh. The present study was designed to determine in vitro antioxidant and thrombolytic activity of n-hexane, dichloromethane and ethyl acetate fractions of C. asiaticum. Antioxidant activity was determined by total phenolic content (TPC) analysis and DPPH radical scavenging assay method. The ethyl acetate fraction showed maximum antioxidant activity (IC50 = 35.44 μg/ml), may be due to the presence of highest amount of phenolic compounds (52.04 mg of GAE per gram of extractives) in this fraction. During thrombolytic assay, dichloromethane fraction of C. asiaticum (Conc.= 10 mg/ml) showed highest 32.59% clot lysis activity. The present study revealed that C. asiaticum possesses significant antioxidant and thrombolytic potential.

Bangladesh J. Sci. Ind. Res. 59(4), 191-194, 2024

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Published

2024-12-30

How to Cite

Islam, M. S., Sharmin Ahmed Rakhi, Kuddus, M. R., Sarkar, M. R., & Ahmed, F. (2024). Antioxidant and thrombolytic activities of Crinum asiaticum L. Bangladesh Journal of Scientific and Industrial Research, 59(4), 191–194. https://doi.org/10.5564/bjsir.v59i4.73758

Issue

Vol. 59 No. 4 (2024)

Section

Articles

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