Spectral correlation of synthesized ethyl-4-(subs. phenyl)-6-methyl-2-oxo (or thio)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate

Authors

  • Md Ershad Halim Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
  • M N Khan Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
  • U Shaha Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
  • M H Rahman Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
  • K Akhter Department of Chemistry, University of Dhaka, Dhaka 1000, Bangladesh
  • S M Ahmed Department of Chemistry, American International University - Bangladesh, 408/1 Kuratoli, Khilkhet, Dhaka-1229, Bangladesh

DOI:

https://doi.org/10.5564/bjsir.v59i4.75654

Keywords:

Biginelli reaction, solvent free condition, Urea and thiourea, substituted aromatic aldehydes.

Abstract

Urea or thiourea, ethyl acetoacetate, and substituted aromatic aldehydes were combined in a one-pot Biginelli coupling reaction to create a few 1, 2, 3, 4-tetrahydro pyrimidine-5-carboxylate derivatives without any unsafe organic solvent. The catalyst used for this reaction was nickel nitrate hexahydrate [Ni(NO3)2.6(H2O)]. The elemental analyses, mass spectral data, 1H-NMR, 13C-NMR, UV, and IR were used to characterize the separated pure products.

Bangladesh J. Sci. Ind. Res. 59(4), 223-230, 2024

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Published

2024-12-30

How to Cite

Halim, M. E., Khan, M. N., Shaha, U., Rahman, M. H., Akhter, K., & Ahmed, S. M. (2024). Spectral correlation of synthesized ethyl-4-(subs. phenyl)-6-methyl-2-oxo (or thio)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate. Bangladesh Journal of Scientific and Industrial Research, 59(4), 223–230. https://doi.org/10.5564/bjsir.v59i4.75654

Issue

Vol. 59 No. 4 (2024)

Section

Articles

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