Serum homocysteine in pre-eclampsia and eclampsia

Authors

  • Md. Mozammel Hoque Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
  • Tania Bulbul Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
  • Monzarin Mahal Department of Biochemistry, Dhaka Medical College, Dhaka, Bangladesh.
  • Nur-A-Farzana Islam Department of Biochemistry, North East Medical College, Sylhet, Bangladesh.
  • Munira Ferdausi Department of Obstetrics and Gynecology, Rajshahi Medical College, Rajshahi, Bangladesh.

DOI:

https://doi.org/10.3329/bmrcb.v34i1.1165

Keywords:

Eclampsia, Homocysteine, Pre-eclampsia, Serum

Abstract

Pre-eclampsia and eclampsia are common obstetrical problem causing adverse effects on pregnancy outcome. Large bodies of evidences suggest that hyperhomocysteinemia is a causal factor of pre-eclampsia/eclampsia. This study designed to explore the association between hyperhomocysteinemia and pre-eclampsia/eclampsia, the knowledge of which expected to be used for prevention of pre-eclampsia and eclampsia. In a case-control study serum homocysteine was measured in 136 controls (healthy pregnant), 84 pre-eclamptic and 120 eclamptic pregnant women. Serum homocysteine in patients with pre-eclampsia (9.54 ± 3.21 µmol/L) and eclampsia (10.57 ± 3.39 µmol/L) found to be significantly increased compared to controls (6.86 ± 2.47 µmol/L)(p<0.001). Between pre-eclampsia and eclampsia, homocysteine found to be raised more in eclampsia compared to pre-eclampsia (p<0.03). In conclusion, hyperhomocysteinemia is associated with pre-eclampsia as well as eclampsia, but in eclampsia the severity of homocysteine elevation is more compared to that in pre-eclampsia.

Keywords: Eclampsia; Homocysteine; Pre-eclampsia; Serum

DOI: 10.3329/bmrcb.v34i1.1165

Bangladesh Med Res Counc Bull 2008; 34: 16-20

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How to Cite

Hoque, M. M., Bulbul, T., Mahal, M., Islam, N.-A.-F., & Ferdausi, M. (2008). Serum homocysteine in pre-eclampsia and eclampsia. Bangladesh Medical Research Council Bulletin, 34(1), 16–20. https://doi.org/10.3329/bmrcb.v34i1.1165

Issue

Vol. 34 No. 1 (2008)

Section

Research Papers

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