HBeAg/anti-HBe, alanine aminotransferase and HBV DNA

Authors

  • Fareha Jesmin Rabbi
  • Md. Kamar Rezwan
  • Tahmina Shirin

DOI:

https://doi.org/10.3329/bmrcb.v34i2.1173

Keywords:

HBeAg/anti-HBe, alanine aminotransferase, HBV DNA, HBsAg positive

Abstract

Serum samples from a total of 72 chronic hepatitis B virus carriers were analysed by serological, biochemical and molecular assays. The aim was to evaluate the relationship of the serological and biochemical parameters with molecular markers in order to assess the infectivity of virus. Out of 72 chronic HBsAg positive carriers, 28 patients were HBeAg positive and anti-HBe negative, 38 patients were HBeAg negative and anti-HBe positive, only 3 patients were positive for both HBeAg and anti-HBe and the rest 3 patients were negative for both markers. Detectable HBV DNA level was found in 92.86% HBsAg-positive/anti-HBe negative patients along with raised alanine aminotransferase (ALT) level (67.86%)  compared with  HBeAg-negative/anti-HBe positive carriers (36.84%) (p value = 0.02) and out a total of 38 HBeAg-negative/anti-HBe positive carriers, 12 (31.58%) patients had detectable level of HBV DNA. Among the 14 HBeAg-negative/anti-HBe positive patients with elevated ALT level, 8 (57.14%) had detectable HBV DNA whereas out of 24 HBeAg-negative/anti-HBe positive patients with normal ALT level only 4 (16.66%) had detectable HBV DNA level. Significantly high rate of detection of HBV DNA was seen among anti-HBe positive patients with raised ALT level compared with the patients  with normal ALT level (p value = 0.01).

Keywords: HBeAg/anti-HBe; alanine aminotransferase, HBV DNA; HBsAg positive

DOI: 10.3329/bmrcb.v34i2.1173

Bangladesh Med Res Counc Bull 2008; 34: 39-43

 

Downloads

Download data is not yet available.
Abstract
210
PDF
390

Downloads

How to Cite

Rabbi, F. J., Rezwan, M. K., & Shirin, T. (2008). HBeAg/anti-HBe, alanine aminotransferase and HBV DNA. Bangladesh Medical Research Council Bulletin, 34(2), 39–43. https://doi.org/10.3329/bmrcb.v34i2.1173

Issue

Vol. 34 No. 2 (2008)

Section

Research Papers

License

Authors who publish with this journal agree to the following terms.

Authors retain copyright and grant the journal right of first publication.

Creative Commons Licence
Articles in the Bangladesh Medical Research Council Bulletin are licensed under a Creative Commons Attribution 4.0 International License (CC-BY) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).