Intraoperative serum parathyroid hormone level is an indicator of hypocalcaemia in total thyroidectomy patients

Authors

  • MS Islam Department of Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • T Sultana Department of Clinical Pathology, BSMMU, Dhaka
  • D Paul Department of Clinical Pathology, BSMMU, Dhaka
  • AHMZ Huq Department of Otolaryngology, BSMMU, Dhaka
  • AA Chowdhury Department of Otolaryngology, BSMMU, Dhaka
  • C Ferdous Uttara Health Care Center, Bangladesh Institute of Health Science, Dhaka
  • ANN Ahmed Department of Clinical Pathology, BSMMU, Dhaka

DOI:

https://doi.org/10.3329/bmrcb.v38i3.14331

Keywords:

Intraoperative serum, parathyroid, hormone, hypocalcaemia, thyroidectomy patients

Abstract

Postoperative hypocalcaemia is the most frequent and common complication after total thyroidectomy. It is necessary to diagnose or to predict hypocalcaemia immediately after total thyroidectomy for minimizing complications. A prospective observational study was carried out in the Department of Clinical Pathology in collaboration with Department of Microbiology & Immunology, Department of Surgery, Department of Otolaryngology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and Department of Otolaryngology, Dhaka Medical College & Hospital (DMC&H), Dhaka, during the period of September 2010 to August 2011 to evaluate intraoperative (20 minutes after total thyroidectomy) parathyroid hormone (PTH) measurement as a predictor of post thyroidectomy hypocalcaemia. Total 65 patients were enrolled in this study those came for total thyroidectomy. Postoperative hypocalcaemia developed in 25 cases. Intraoperative PTH was assessed and significant correlation was found between intraoperative PTH level and development of hypocalcaemia. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value of intraoperative serum PTH for prediction of post total thyroidectomy hypocalcaemia were 84.0%, 85.0%, 84.6%, 77.8%, and 89.5% respectively. Because of the high sensitivity, specificity and accuracy of intraoperative serum PTH of this study, the early prediction of hypocalcaemia could be made by single assay of intraoperative serum PTH level at 20 minutes after total thyroidectomy.

DOI: http://dx.doi.org/10.3329/bmrcb.v38i3.14331

Bangladesh Med Res Counc Bull 2012; 38(3): 84-89 (December)

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Published

2013-03-29

How to Cite

Islam, M., Sultana, T., Paul, D., Huq, A., Chowdhury, A., Ferdous, C., & Ahmed, A. (2013). Intraoperative serum parathyroid hormone level is an indicator of hypocalcaemia in total thyroidectomy patients. Bangladesh Medical Research Council Bulletin, 38(3), 84–89. https://doi.org/10.3329/bmrcb.v38i3.14331

Issue

Vol. 38 No. 3 (2012)

Section

Research Papers

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