Hepatitis B surface antigen-negative, but HBV DNA-positive patients in Bangladesh

Authors

  • MA Mahtab Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • SMF Akbar Department of Medical Sciences, Toshiba General Hospital, Tokyo
  • S Rahman Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka

DOI:

https://doi.org/10.3329/bmrcb.v38i3.14337

Keywords:

Hepatitis B, antigen-negative, HBV DNA-positive,

Abstract

Hepatitis B surface antigen (HBsAg) is regarded as sole marker of hepatitis B virus (HBV) infection in Bangladesh and most other developing countries. However, some HBV-negative subjects may harbor HBV DNA and transfusion of their blood may cause HBV infection in recipients. HBV DNA was checked in 20 patients with cryptogenic liver cirrhosis, 10 patients with hepatocellular carcinoma without any known etiology, and 10 apparently healthy subjects with elevated levels of serum alanine aminotransferase (ALT). HBV DNA was detected in 8 of 20 patients with cryptogenic liver cirrhosis, 1 of 10 patients with hepatocellular carcinoma, and 2 of 10 apparent healthy subjects with elevated ALT. However, all of them were negative for HBsAg in the sera. This study indicates that some additional mechanisms should be developed for detection of HBsAg-negative HBV-infected subjects for efficient control and management of HBV infection in Bangladesh.

DOI: http://dx.doi.org/10.3329/bmrcb.v38i3.14337

Bangladesh Med Res Counc Bull 2012; 38(3): 104-107 (December)

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Published

2013-03-30

How to Cite

Mahtab, M., Akbar, S., & Rahman, S. (2013). Hepatitis B surface antigen-negative, but HBV DNA-positive patients in Bangladesh. Bangladesh Medical Research Council Bulletin, 38(3), 104–107. https://doi.org/10.3329/bmrcb.v38i3.14337

Issue

Vol. 38 No. 3 (2012)

Section

Research Papers

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