Serotype and serovar distribution of Neisseria gonorrhoeae isolated from high-risk populations in Bangladesh

Authors

  • MA Alam Department of Parasitology, IEDCR, Dhaka
  • MZ Chowdhury Department of Microbiology and Director, National Institute of Preventive and Social Medicine (NIPSOM), Dhaka
  • F Ahmed Molecular and Serodiagnostic Laboratory, Clinical Services Laboratory, ICDDR,B, Dhaka
  • A Alam RTI/STI Laboratory, ICDDR,B, Dhaka
  • MA Hossain Clinical Services Laboratory, ICDDR,B, Dhaka

DOI:

https://doi.org/10.3329/bmrcb.v38i3.14339

Keywords:

Serotype, serovar, Neisseria gonorrhoeae, high-risk populations

Abstract

Neisseria gonorrhoeae, the causative agent of gonococcal infection, is known to frequently change their characteristics to evade host immune mechanism. Characterization of the clinical isolates of the organism can lead to identification of the circulating strains and often a sexual network in a community to help in designing the control strategy. Keeping in mind the above consideration, a total of 239 N. gonorrhoeae, isolated from high-risk populations, were characterized for serotypes and serovars by monoclonal antibodies against protein I of the organism. Majority of the serotypes were serotype B (142, 59.4%). Majority of the isolates showing resistance to at least one of the antibiotics tested were also serotype B (139, 59.2%), whereas, majority of the isolates showing resistance to any three of the antibiotics (multidrug resistant, MDR) (63%) was serotype A. A total of 41 different serovars were also identified and five of which (Arst, Bropt, Bopt, Arost, and Brop) included the highest percent (49.3%) of the isolates. Many serovars (23/41, 56.1%) were new emergent and included 58 (24.3%) of the isolates investigated. All of the new serovars were resistant to at least one of the antibiotics tested and the highest rate (40/102, 39.2%) was MDR. Serotyping and serovar determination was found contributory to understand the microepidemics of the N. gonorrhoeae isolates. Further studies including antibiogram and contact tracing can efficiently help in control of the disease.

DOI: http://dx.doi.org/10.3329/bmrcb.v38i3.14339

Bangladesh Med Res Counc Bull 2012; 38(3): 114-118 (December)

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Published

2013-03-30

How to Cite

Alam, M., Chowdhury, M., Ahmed, F., Alam, A., & Hossain, M. (2013). Serotype and serovar distribution of Neisseria gonorrhoeae isolated from high-risk populations in Bangladesh. Bangladesh Medical Research Council Bulletin, 38(3), 114–118. https://doi.org/10.3329/bmrcb.v38i3.14339

Issue

Vol. 38 No. 3 (2012)

Section

Research Papers

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