Leptin to adiponectin ratio in preeclampsia
DOI:
https://doi.org/10.3329/bmrcb.v39i1.15805Keywords:
Leptin, adiponectin, preeclampsiaAbstract
The aim of the present study was to assess leptin/adiponectin ratio in preeclamptic patients compared with normal pregnant women. A cross-sectional study was designed. The study population consisted of 30 preeclamptic patients and 30 healthy pregnant women. Serum levels of total leptin and adiponectin were assessed using commercially available enzyme-linked immunosorbent assay methods. The oneway ANOVA and Students t tests and Pearsons correlation analysis were used for statistical calculations. Levels of leptin and adiponectin were also adjusted for BMI. A p-value <0.05 was considered statistically significant. The leptin/adiponectin ratio was increased significantly in preeclamptic patients. The leptin/adiponectin ratio was significantly higher in severe preeclamptic patient than in mild preeclampsia. Adjusted leptin/adiponectin ratio was also significantly increased in preeclamptic patients than in normal pregnant women. The findings of the present study suggest that the leptin/adiponectin ratio was increased in preeclamsia and imbalance between the adipocytokines could be involved in the pathogenesis of preeclampsia.
DOI: http://dx.doi.org/10.3329/bmrcb.v39i1.15805
Bangladesh Med Res Counc Bull 2013; 39: 18-21
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