Disseminated intravascular coagulation in acute promyelocytic leukaemia and its impact on the induction failure: a single centre study

Authors

  • F Rahman Dept. of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • AL Kabir Dept. of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • MR Khan Dept. of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • A Aziz Dept. of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • MN Baqui Dept. of Pathology,Sir Salimullah Medical College and Mitford Hospital Dhaka
  • TF Dipta Dept. of Transfusion Medicine, BIRDEM and Ibrahim Medical College, Dhaka
  • ABM Yunus Dept. of Haematology, Bangabandhu Sheikh Mujib Medical University, Dhaka,

DOI:

https://doi.org/10.3329/bmrcb.v39i2.19642

Abstract

Life-threatening coagulopathy associated with acute promyelocytic leukemia (APL) has been the defining clinical characteristic and is an important risk factor for fatal haemorrhage and early death. Pathogenesis of coagulopathy in APL is complex and mainly includes disseminated intravascular coagulation (DIC). The study was done to see the status of DIC and its impact on the outcome of APL in our setting. Among the total 60 patients, induction mortality rate was 30% and remission rate was 70%. The main cause of induction mortality was bleeding that accounts for 66.7% of mortality. DIC was present among 32 out of 60 patients (53.33%). Induction mortality has significant relationship to DIC as the induction mortality rate is 47% in patients with DIC and 11% in patient without DIC (P value 0.0009 ). Induction motality rate in low, intermediate and high risk group is 6.7%, 24% and 58% respectively (p value <0.0001). Finally, risk group subclassification revealed presence of DIC in high risk group has the highest early mortality rate

DOI: http://dx.doi.org/10.3329/bmrcb.v39i2.19642

Bangladesh Med Res Counc Bull 2013; 39: 57-60

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Published

2014-07-23

How to Cite

Rahman, F., Kabir, A., Khan, M., Aziz, A., Baqui, M., Dipta, T., & Yunus, A. (2014). Disseminated intravascular coagulation in acute promyelocytic leukaemia and its impact on the induction failure: a single centre study. Bangladesh Medical Research Council Bulletin, 39(2), 57–60. https://doi.org/10.3329/bmrcb.v39i2.19642

Issue

Section

Research Papers