Effect of chronic smoking on lipid peroxidation and antioxidant status in gastric carcinoma patients

Authors

  • Palanisamy Pasupathi Corresponding author
  • Palanisamy Chinnaswamy Co-author
  • Ganesan Saravanan Co-author
  • Utharasamy Senthil Kumar Co-author

DOI:

https://doi.org/10.3329/bmrcb.v35i1.2132

Keywords:

Antioxidant, Gastric carcinoma, Lipid peroxidation, Smoking

Abstract

The effect of chronic cigarette smoking on lipid peroxidation and antioxidant status in 100 newly diagnosed patients with gastric cancer was studied. Equal number of age- and sex-matched healthy control subjects was taken as control. The level of plasma and erythrocyte thiobarbituric acid reactive substances (TBARS) was markedly increased in both the gastric cancer patients when compared to control subjects. The activities of enzymatic and non-enzymatic antioxidants were significantly decreased in both (smokers and non-smokers) gastric cancer groups when compared to control subjects. Comparatively, the increased TBARS level and decreased antioxidants level was observed in smokers than non-smoking gastric cancer patients. The present study highlights the occurrence of lipid peroxidation and possible breakdown of antioxidant status in cigarette smoking, which may subsequently increase the possibility of initiation and progression of gastric cancer.

Keywords: Antioxidant; Gastric carcinoma; Lipid peroxidation; Smoking

Online: 20 May 2009

DOI: 10.3329/bmrcb.v35i1.2132

Bangladesh Med Res Counc Bull 2009; 35: 1-6

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Published

2009-05-15

How to Cite

Pasupathi, P., Chinnaswamy, P., Saravanan, G., & Senthil Kumar, U. (2009). Effect of chronic smoking on lipid peroxidation and antioxidant status in gastric carcinoma patients. Bangladesh Medical Research Council Bulletin, 35(1), 1–6. https://doi.org/10.3329/bmrcb.v35i1.2132

Issue

Section

Research Papers