Role of ascitic fluid adenosine deaminase (ADA) and serum CA-125 in the diagnosis of tuberculous peritonitis

Authors

  • N Ali Department of Gastroenterology, Rangpur Medical College & Hospital, Rangpur
  • NC Nath Department of Gastroenterology, Sir Salimullah Medical College & Mitford Hospital, Dhaka
  • R Parvin Department of Radiology, Rangpur Medical College & Hospital, Rangpur
  • A Rahman Department of GHPD, BIRDEM, Dhaka
  • TM Bhuiyan Department of GHPD, BIRDEM, Dhaka
  • M Rahman Department of GHPD, BIRDEM, Dhaka
  • MN Mohsin RP (Medicine), Cox?s Bazar Medical College, Cox?s Bazar

DOI:

https://doi.org/10.3329/bmrcb.v40i3.25228

Abstract

This cross sectional study was carried out in the department of gastroenterology, BIRDEM, Dhaka from January 2010 to May 2011 to determine the role of ascitic fluid ADA and serum CA-125 in the diagnosis of clinically suspected tubercular peritonitis. Total 30 patients (age 39.69±21.26, 18M/12F) with clinical suspicion of tuberculosis peritonitis were included in this study after analyzing selection criteria. Laparoscopic peritoneal biopsy with histopathological diagnosis was considered gold standard against which accuracics of two biomarkers (ADA & CA-125) were compared. Cut off value of ADA and CA-125 are 24 u/l, 35 U/ml respectively. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of ADA as a diagnostic modality in tuberculos peritonitis were 87.5%, 83.33%, 95.45%, 62.5% and 86.67% respectively where as CA-125 was found to have 83.33% sensitivity, 50% specificity, 86.9% positive predictive value, 42.85% negative predictive value and 76.6% accuracy. Both biomarkers are simple, non-invasive, rapid and relatively cheap diagnostic test where as laparoscopy is an invasive procedure, costly & requires trained staff and not without risk and also not feasible in all the centre in our country. So ascitic fluid ADA and serum CA-125 are important diagnostic test for peritoneal tuberculosis.

Bangladesh Med Res Counc Bull 2014; 40 (3): 89-91

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Author Biography

N Ali, Department of Gastroenterology, Rangpur Medical College & Hospital, Rangpur



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Published

2015-10-05

How to Cite

Ali, N., Nath, N., Parvin, R., Rahman, A., Bhuiyan, T., Rahman, M., & Mohsin, M. (2015). Role of ascitic fluid adenosine deaminase (ADA) and serum CA-125 in the diagnosis of tuberculous peritonitis. Bangladesh Medical Research Council Bulletin, 40(3), 89–91. https://doi.org/10.3329/bmrcb.v40i3.25228

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Section

Research Papers