Elevated serum ?hCG and dyslipidemia in second trimester as predictors of subsequent Pregnancy Induced Hypertension
Objectives: To test the hypothesis that pregnant women with high serum ?hCG level and serum dyslipidemia in second trimester are more prone to develop subsequent Pregnancy Induced Hypertension (PIH). Materials & Methods: One hundred pregnant women with singleton pregnancy between 14 and 20 weeks of gestation attending antenatal outpatient department (OPD) of SMCH were studied. Serum ?hCG was estimated by two-site chemiluminescent-immunometric method. Serum lipid profile was evaluated by enzymatic colorimetric test with Lipid Clearing Factor (LCF). Results: Eighteen cases developed PIH while eighty two cases remained normotensive. The serum ?hCG level was significantly high (p?0.001) in those women developing PIH. Serum concentration of total cholesterol in women who subsequently developed PIH was significantly higher than that of normotensive group (p ?0.05). Mean TG value in PIH group was higher than the normotensive group. Level of LDL in PIH group was also significant (p?0.05). Conclusion: Present study showed that elevated serum ?hCG and Dyslipidemia in second trimester can be considered as predictors of subsequent PIH / Pre-eclampsia. However, there is need of large community based prospective study to validate the result.
Bangladesh Med Res Counc Bull 2014; 40 (3): 97-101
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