HLA-B27 antigen frequency among suspected Spondyloarthropathy patients attaining a tertiary level hospital of Bangladesh

Authors

  • A Nessa Tissue Typing Laboratory, Dept. of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • S Tabassum Tissue Typing Laboratory, Dept. of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • S Sultana Tissue Typing Laboratory, Dept. of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka

DOI:

https://doi.org/10.3329/bmrcb.v40i3.25231

Abstract

Human leukocyte antigen B27 (HLA-B27), a class I molecules of the major histocompatibility complex has a strong disease association with different types of spondarthropathies (SpA). The strength of this disease association varies markedly among racial and ethnic populations. The present study aimed to identify the HLA-B27 antigen frequencies among suspected SpA patients as well as healthy Bangladeshi individuals. The frequency of HLA-B27 was determined in 1500 patients and 1000 healthy subjects attending the Bangabandhu Sheikh Mujib Medical University (BSMMU). HLAB 27 typing was done by microlymphocytotoxicity test using commercial kit. A total of 738 (49.2%) suspected SpA patients and 107 (10.7%) healthy subjects tested positive for HLA-B27 antigen with higher frequency among younger age groups (54.9%, 52.4% and 56.2% in 0-14 years, 15-24 years and 2534 years of age respectively). The male female positivity was almost same (11.4% and 9.6%) among control group, but in patient group it was 53.0% and 41.2% respectively. The findings of this hospital based study showed a high frequency of HLA-B27 among suspected SpA patients with male preponderance which is comparable with neighboring countries.

Bangladesh Med Res Counc Bull 2014; 40 (3): 102-106

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Author Biography

A Nessa, Tissue Typing Laboratory, Dept. of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka



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Published

2015-10-05

How to Cite

Nessa, A., Tabassum, S., & Sultana, S. (2015). HLA-B27 antigen frequency among suspected Spondyloarthropathy patients attaining a tertiary level hospital of Bangladesh. Bangladesh Medical Research Council Bulletin, 40(3), 102–106. https://doi.org/10.3329/bmrcb.v40i3.25231

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Section

Research Papers