HLA-B27 antigen frequency among suspected Spondyloarthropathy patients attaining a tertiary level hospital of Bangladesh

Authors

  • A Nessa Tissue Typing Laboratory, Dept. of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • S Tabassum Tissue Typing Laboratory, Dept. of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • S Sultana Tissue Typing Laboratory, Dept. of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka

DOI:

https://doi.org/10.3329/bmrcb.v40i3.25231

Abstract

Human leukocyte antigen B27 (HLA-B27), a class I molecules of the major histocompatibility complex has a strong disease association with different types of spondarthropathies (SpA). The strength of this disease association varies markedly among racial and ethnic populations. The present study aimed to identify the HLA-B27 antigen frequencies among suspected SpA patients as well as healthy Bangladeshi individuals. The frequency of HLA-B27 was determined in 1500 patients and 1000 healthy subjects attending the Bangabandhu Sheikh Mujib Medical University (BSMMU). HLAB 27 typing was done by microlymphocytotoxicity test using commercial kit. A total of 738 (49.2%) suspected SpA patients and 107 (10.7%) healthy subjects tested positive for HLA-B27 antigen with higher frequency among younger age groups (54.9%, 52.4% and 56.2% in 0-14 years, 15-24 years and 2534 years of age respectively). The male female positivity was almost same (11.4% and 9.6%) among control group, but in patient group it was 53.0% and 41.2% respectively. The findings of this hospital based study showed a high frequency of HLA-B27 among suspected SpA patients with male preponderance which is comparable with neighboring countries.

Bangladesh Med Res Counc Bull 2014; 40 (3): 102-106

Downloads

Download data is not yet available.
Abstract
166
PDF
172

Author Biography

A Nessa, Tissue Typing Laboratory, Dept. of Virology, Bangabandhu Sheikh Mujib Medical University, Dhaka



Downloads

Published

2015-10-05

How to Cite

Nessa, A., Tabassum, S., & Sultana, S. (2015). HLA-B27 antigen frequency among suspected Spondyloarthropathy patients attaining a tertiary level hospital of Bangladesh. Bangladesh Medical Research Council Bulletin, 40(3), 102–106. https://doi.org/10.3329/bmrcb.v40i3.25231

Issue

Vol. 40 No. 3 (2014)

Section

Research Papers

License

Authors who publish with this journal agree to the following terms.

Authors retain copyright and grant the journal right of first publication.

Creative Commons Licence
Articles in the Bangladesh Medical Research Council Bulletin are licensed under a Creative Commons Attribution 4.0 International License (CC-BY) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).