Corn extracts lower tissue arsenic level in rat

Authors

  • Noor Jahan Alam Chowdhury
  • Mir Misbahudddin
  • Md. Sayedur Rahman

DOI:

https://doi.org/10.3329/bmrcb.v35i1.2533

Keywords:

Arsenic, Corn, Rat

Abstract

This study was carried out to see whether corn extracts could reduce the accumulation of arsenic in different tissues of rat. Exposure to arsenic (700µg/rat/day) orally for 15 days led to significant accumulation of arsenic and significant reduction in the concentration of reduced glutathione (GSH) in different tissues. While water, salt, ethanol and alkali extracts of corn were co-administered at a dose of 0.5 mL/rat/day orally by stomach tube during last 8 days, arsenic concentration decreased significantly in all tissues and reduced glutathione (GSH) concentration increased significantly in tissues except heart and skin. Among the extracts, water extract produced maximum reduction of arsenic (69.07% in liver, 64.98% in kidney, 63.47% in lung, 57.55% in heart and 69.30% in skin) and elevation of reduced glutathione level in all tissues (17.03% in liver, 46.73% in lung, 32.67% in heart and 55.38% in skin) except kidney, in which maximum elevation of reduced glutathione was attained by ethanol extract (23.14%). This study suggests that corn extracts might protect rats from accumulation of arsenic in different tissues and oxidative stress, which is reflected by the increasing reduced glutathione concentration in those tissues.

Keywords: Arsenic; Corn; Rat

Online: 23 May 2009

Bangladesh Med Res Counc 2009; 35: 21-25  

DOI: 10.3329/bmrcb.v35i1.2533

Downloads

Download data is not yet available.
Abstract
117
PDF
132

Downloads

Published

2009-05-22

How to Cite

Chowdhury, N. J. A., Misbahudddin, M., & Rahman, M. S. (2009). Corn extracts lower tissue arsenic level in rat. Bangladesh Medical Research Council Bulletin, 35(1), 21–25. https://doi.org/10.3329/bmrcb.v35i1.2533

Issue

Vol. 35 No. 1 (2009)

Section

Research Papers

License

Authors who publish with this journal agree to the following terms.

Authors retain copyright and grant the journal right of first publication.

Creative Commons Licence
Articles in the Bangladesh Medical Research Council Bulletin are licensed under a Creative Commons Attribution 4.0 International License (CC-BY) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).