Circulating lipid peroxidation, plasma and erythrocyte antioxidant status in patients with rheumatoid arthritis

Authors

  • Palanisamy Pasupathi Corresponding author
  • Mathiyalagan Deepa Co-author
  • P. Rani Co-author
  • R. Ramesh Sankar Co-author

DOI:

https://doi.org/10.3329/bmrcb.v35i2.2798

Keywords:

Antioxidant, Lipid peroxidation, Rheumatoid arthritis

Abstract

The aim of the study was to investigate the levels of lipid peroxidation, and both plasma and erythrocyte antioxidant states in patients with rheumatoid arthritis. The population consisted of 60 subjects divided into two groups, 30 subjects had evidence of rheumatoid arthritis and age and sex matched healthy subjects were studied as controls. The level of plasma and erythrocyte thiobarbituric acid reactive substances (TBARS) was markedly increased in both the rheumatoid arthritis patients when compared to control subjects. The activities of plasma and erythrocyte antioxidants were significantly decreased in rheumatoid arthritis. C reactive protein, rheumatoid factor and antistreptolysin-O were significantly higher in rheumatoid arthritis patients than in healthy subjects. In conclusion, on the basis of enhanced lipid peroxidation in rheumatoid arthritis patients with concomitant failure of both the plasma, and erythrocyte antioxidants defense mechanism. These results are consistent with the underlying hypothesis that there is an  imbalance between reactive oxygen species production and the antioxidant defense system in inflammatory rheumatoid arthritis disease.

Keywords: Antioxidant; Lipid peroxidation; Rheumatoid arthritis

Online: 13 August 2009

DOI: 10.3329/bmrcb.v35i2.2798

Bangladesh Med Res Counc Bull 2009; 35: 57-62

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Published

2009-08-12

How to Cite

Pasupathi, P., Deepa, M., Rani, P., & Sankar, R. R. (2009). Circulating lipid peroxidation, plasma and erythrocyte antioxidant status in patients with rheumatoid arthritis. Bangladesh Medical Research Council Bulletin, 35(2), 57–62. https://doi.org/10.3329/bmrcb.v35i2.2798

Issue

Vol. 35 No. 2 (2009)

Section

Research Papers

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