Free radicals and antioxidant status in acute myocardial infarction patients with and without diabetes mellitus

Authors

  • Mathiyalagan Deepa Department of Laboratory Medicine, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu
  • Palanisamy Pasupathi Department of Laboratory Medicine, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu
  • K.B. Vidhya Sankar Department of Radiology, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu
  • P. Rani Department of Gynecology, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu
  • S.P. Satish Kumar Department of Diabetologe, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu

DOI:

https://doi.org/10.3329/bmrcb.v35i3.2999

Keywords:

Diabetes mellitus, Oxidative stress, acute myocardial Infarction, Antioxidant status

Abstract

In this study we investigated the oxidative stress, antioxidants and inflammatory molecules in patients of acute myocardial infarction (AMI) with diabetes (n=50) and non-diabetes (n=50). Fifty healthy subjects were taken as control. The levels of plasma TBARS and ceruloplasmin levels were significantly high in diabetic and non-diabetic AMI patients as compared with control. On the other hand, the activities of both enzymatic and non-enzymatic antioxidants were significantly decreased in diabetic and non-diabetic AMI patients as compared with control. Inflammatory markers showed significant rise in diabetic patients as compared with controls. Our results show increased inflammation and oxidative stress in patients with AMI, and magnitude of imbalance is greater in diabetic AMI patients, possibly because of greater inflammation in diabetic patients.

Keywords: Acute myocardial infarction; Antioxidant; Free radical; Diabetes mellitus

Online: 8 Feb 2010

DOI: http://dx.doi.org/10.3329/bmrcb.v35i3.2999

Bangladesh Med Res Counc Bull 2009; 35: 95-100

 

 

 

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Published

2010-02-07

How to Cite

Deepa, M., Pasupathi, P., Sankar, K. V., Rani, P., & Kumar, S. S. (2010). Free radicals and antioxidant status in acute myocardial infarction patients with and without diabetes mellitus. Bangladesh Medical Research Council Bulletin, 35(3), 95–100. https://doi.org/10.3329/bmrcb.v35i3.2999

Issue

Vol. 35 No. 3 (2009)

Section

Research Papers

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