Free radicals and antioxidant status in acute myocardial infarction patients with and without diabetes mellitus

Authors

  • Mathiyalagan Deepa Department of Laboratory Medicine, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu
  • Palanisamy Pasupathi Department of Laboratory Medicine, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu
  • K.B. Vidhya Sankar Department of Radiology, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu
  • P. Rani Department of Gynecology, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu
  • S.P. Satish Kumar Department of Diabetologe, Raajam Hospital, Karruppur, Salem 636 012, Tamil Nadu

DOI:

https://doi.org/10.3329/bmrcb.v35i3.2999

Keywords:

Diabetes mellitus, Oxidative stress, acute myocardial Infarction, Antioxidant status

Abstract

In this study we investigated the oxidative stress, antioxidants and inflammatory molecules in patients of acute myocardial infarction (AMI) with diabetes (n=50) and non-diabetes (n=50). Fifty healthy subjects were taken as control. The levels of plasma TBARS and ceruloplasmin levels were significantly high in diabetic and non-diabetic AMI patients as compared with control. On the other hand, the activities of both enzymatic and non-enzymatic antioxidants were significantly decreased in diabetic and non-diabetic AMI patients as compared with control. Inflammatory markers showed significant rise in diabetic patients as compared with controls. Our results show increased inflammation and oxidative stress in patients with AMI, and magnitude of imbalance is greater in diabetic AMI patients, possibly because of greater inflammation in diabetic patients.

Keywords: Acute myocardial infarction; Antioxidant; Free radical; Diabetes mellitus

Online: 8 Feb 2010

DOI: http://dx.doi.org/10.3329/bmrcb.v35i3.2999

Bangladesh Med Res Counc Bull 2009; 35: 95-100

 

 

 

Downloads

Download data is not yet available.
Abstract
135
PDF
67

Downloads

Published

2010-02-07

How to Cite

Deepa, M., Pasupathi, P., Sankar, K. V., Rani, P., & Kumar, S. S. (2010). Free radicals and antioxidant status in acute myocardial infarction patients with and without diabetes mellitus. Bangladesh Medical Research Council Bulletin, 35(3), 95–100. https://doi.org/10.3329/bmrcb.v35i3.2999

Issue

Vol. 35 No. 3 (2009)

Section

Research Papers

License

Authors who publish with this journal agree to the following terms.

Authors retain copyright and grant the journal right of first publication.

Creative Commons Licence
Articles in the Bangladesh Medical Research Council Bulletin are licensed under a Creative Commons Attribution 4.0 International License (CC-BY) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).