Inhibitory effect of arsenic on aerobic gut flora in rat

Authors

  • Zubaida Khatoon Choudhry Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Mir Misbahuddin Department of Pharmacology, Sylhet MAG Osmani Medical College, Sylhet
  • A.K.M. Mosharrof Hossain Department of Pharmacology, Sylhet MAG Osmani Medical College, Sylhet
  • Ahmed Abu Saleh Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bmrcb.v35i3.4205

Keywords:

Aerobic, Arsenic, Gut flora, Rat

Abstract

An in vivo study was carried on rats to see the influence of arsenic on aerobic gut flora. A significant inhibition of gut flora was observed after 2 weeks of administration of arsenic (1 mg/L) ad libitum with a decrease in stool arsenic level and increase in liver arsenic level. However, this inhibitory effect of arsenic on gut flora was not observed in presence of vitamin E (1 mg/day) or selenium (0.4 mg/day). Pretreatment with streptomycin (500 mg twice daily) showed similar results. Rats that received folic acid (200 mg/day) showed inhibition of gut floral count but there were decreased liver arsenic level.

Keywords: Aerobic; Arsenic; Gut flora; Rat

Online: 8 Feb 2010

DOI: http://dx.doi.org/10.3329/bmrcb.v35i3.4205

Bangladesh Med Res Counc Bull 2009; 35: 79-83

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Published

2010-02-07

How to Cite

Choudhry, Z. K., Misbahuddin, M., Hossain, A. M., & Saleh, A. A. (2010). Inhibitory effect of arsenic on aerobic gut flora in rat. Bangladesh Medical Research Council Bulletin, 35(3), 79–83. https://doi.org/10.3329/bmrcb.v35i3.4205

Issue

Vol. 35 No. 3 (2009)

Section

Research Papers

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