Sympathetic cardiovascular function status of chronic obstructive pulmonary disease (COPD)
Keywords:Sympathetic dysfunction, COPD, Isometric exercise test, Orthostatic test
Background: Chronic obstructive pulmonary disease (COPD) is a chronic progressive obstructive airway disease which is often associated with cardiovascular diseases. Sympathetic dysfunction may complicate the cardiovascular diseases which may in turn increase the morbidity and mortality in COPD patients.
Objective: Aim of this study was to evaluate sympathetic cardiovascular function status of COPD patients to reduce the cardiovascular complication in those patients.
Methods: This comparative cross-sectional study was carried out at the department of Physiology and department of Medicine, Rajshahi Medical College, Rajshahi from July 2013 to June 2014.
Results: A total number of 80 subjects aged 40-55 years were selected, among which 40 were clinically diagnosed COPD patients (case) and 40 were age, sex and BMI matched apparently healthy persons for comparison (control group). To observe sympathetic cardiovascular function status resting pulse rate, resting systolic BP, resting diastolic BP, decline of systolic BP in response to standing from lying position (orthostatic test) and rise of diastolic BP in response to sustained hand grip for 5 minutes (isometric exercise test) were measured. For statistical analysis Independent sample t-test, and Pearson’s correlation coefficient test were performed. In this study resting pulse rate, systolic BP, diastolic BP and rise of diastolic blood pressure in isometric exercise test were significantly increased in COPD than in healthy control group. On the other hand, decline of systolic blood pressure in orthostatic test was significantly decreased in COPD than in control group.
Conclusion: This study concludes that sympathetic cardiovascular function is overactive in COPD and sympathetic over activity correlates with severity of the disease.
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