Effect of glycemic control on thyroid hormones level in type 2 diabetic patients
Keywords:Thyroid stimulating hormone, free thyroxine, free triiodothyronine, Type 2 Diabetes Mellitus, Glycaemic controls
Background: Thyroid dysfunction, a common endocrine disorder that increasing day by day. Hypothyroidism occasionally occurs in diabetic patients especially those with poor glycemic control.
Objectives: The objective of the study was to observe the effect of glycemic control on thyroid hormones level in type 2 diabetic patients & to determine selected socio-demographic characteristics of the respondents.
Methods: This was a case control study carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from July 2016 to June 2017. Total sixty subjects of both male and female age ranged from 40 to 60 years were included in this study. Among them thirty were type 2 diabetic patients (both uncontrolled and controlled) and another thirty were included for comparison as control and were matched by age, sex, and body mass index (BMI). Both case and control group were selected purposively based on selection criteria. Serum TSH, FT4 and FT3 levels were measured by chemiluminescent micro particle immunoassay (CMIA) method. Fasting blood glucose level was estimated by glucose oxidase (GOD) method and blood HbA1c level was estimated by ion exchange high performance liquid chromatography (HPLC) method. The statistical analysis was done by ANOVA test, Bonferroni test and Pearson’s correlation coefficient test. Data quality control was done by using a checklist.
Results: In this study, mean serum TSH level was significantly higher in uncontrolled diabetic patients than that of controlled diabetic patients. Serum FT4 level was significantly lower in uncontrolled diabetic patients in comparison to that of controlled diabetic patients. Besides these, serum TSH level was positively correlated (r = +0.575), serum FT4 and FT3 levels were negatively correlated (r = ̶ 0.588, r = ̶ 0.527) with HbA1c level in uncontrolled diabetic patients and all these relationships were statistically significant p≤0.05 respectively.
Conclusion: The present study revealed that hypothyroidism occurs in type 2 diabetic patients which were found only in uncontrolled diabetic patients due to their poor glycemic control.
Bangladesh Med Res Counc Bull 2020; 46(1): 29-34
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