Evaluation of myocardial protection in off-pump vs on-pump coronary bypass surgery by troponin I estimation

Authors

  • Md. Badruzzaman Assistant Registrar, Department of Cardiovascular Surgery, National Institute of Cardiovascular Diseases (NICVD), Dhaka
  • Aslam Hossain Assistant Professor, Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University
  • Asit Baran Adhikary Professor, Department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University
  • Sayed Abdul Quader Assistant Registrar, Department of Cardiovascular Surgery, National Institute of Cardiovascular Diseases (NICVD), Dhaka
  • Sarwar Kamal Assistant Registrar, Department of Cardiovascular Surgery, National Institute of Cardiovascular Diseases, (NICVD), Dhaka
  • Sanjoy Kumar Saha Consultant, Department of Cardiovascular & Thoracic Anaesthesiology, Z H Sikder Women's Medical College Hospital

DOI:

https://doi.org/10.3329/bmrcb.v36i3.5080

Keywords:

Myocardial injury, Off-pump and On-pump, Myocardial protection

Abstract

Background: This prospective non-randomized clinical study was done to compare Off-pump and Onpump myocardial revascularization by Troponin I release in patients undergoing first elective coronary artery bypass graft used to evaluate myocardial injury.

Methods: One hundred an twenty patients were non-randomly assigned to a Off-pump or On-pump myocardial revascularization group. Cardiac Troponin I (CTnI) were measured in serial venous blood samples drawn preoperatively in both groups. In On-pump group after aortic unclamping at 12 and 24 hours and in Off-pump group after the last distal anastomosis at 12 and 24 hours.

Results: The total amount of CTnI release were significantly higher in On-pump group than in Off-pump group. In On-pump group it was 2.1±1.9 (mean±SD) ng/ml vs in Off-pump group it was 1.0±1.7 (mean±SD) ng/ml at 12 hours and in On-pump group it was 1.6±1.6 (mean±SD) ng/ml vs in Off-pump group it was .9±1.6 (mean±SD) ng/ml at 24 hours (P<0.0001 for the pattern).

Conclusion: The lower release of CTnI in the Off-pump myocardial revascularization group indicates that the arrested heart coronary revascularization group causes more damage to the heart due to cardiopulmonary bypass than Off-pump myocardial revascularization group.

DOI: 10.3329/bmrcb.v36i3.5080

Bangladesh Med Res Counc Bull 2010; 36: 93-96

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Published

2011-03-18

How to Cite

Badruzzaman, M., Hossain, A., Adhikary, A. B., Quader, S. A., Kamal, S., & Saha, S. K. (2011). Evaluation of myocardial protection in off-pump vs on-pump coronary bypass surgery by troponin I estimation. Bangladesh Medical Research Council Bulletin, 36(3), 93–96. https://doi.org/10.3329/bmrcb.v36i3.5080

Issue

Vol. 36 No. 3 (2010)

Section

Research Papers

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