Correlation of Preoperative Level of Serum Ca125 with Surgical Staging of Ovarian Cancer

Serum CA125 level in ovarian cancer staging

Authors

  • Zulaikha Mohamed Department of Obstetrics and Gynaecology, Indira Gandhi Memorial Hosopital, Male, Maldives.
  • Shirin Akter Begum Department of Gynaecological Oncology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh.
  • Tasfia Mahmud Department of Pharmacology, Sirajul Islam Medical College, Dhaka, Bangladesh.
  • Mehriban Amatullah Department of Gynaecological Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
  • Afroza Khanom Department of Gynaecological Oncology, National Institute of Cancer Research Institute and Hospital, Dhaka, Bangladesh.

DOI:

https://doi.org/10.3329/bmrcb.v47i2.57768

Keywords:

CA-125, Surgical staging, Ovarian cancer, Serous tumour

Abstract

Background: Ovarian cancer is one of the leading cause of mortality and morbidity of gynaecological malignancies. Lack of early demonstration of symptoms and lack of effective screening tests, ovarian tumours are usually diagnosed at an advanced stage. Different studies shows the association of pre-operative serum CA125 level with the surgical staging of ovarian cancer.

Objective: To find out the correlation of pre-operative level of serum CA 125 with the surgical staging (FIGO-2014) of ovarian cancer.

Methodology: This cross sectional study was carried out among 81 subjects in the department of gynaecological oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from August 2018 to September 2019. Sampling technique was purposive. All consecutive patients admitted at department of gynaecological oncology, BSMMU with diagnosed ovarian cancer were included in this study. Data were collected and documented on a preformed and pretested structured questionnaire. Clinical examinations and relevant investigations were done and recorded accordingly.

Result: Mean age of the study subjects was 45.7 ± 15.2 years with a range of 13-75 years. Mean BMI was 23.3 ±

3.0 kg/m2 and mean age of marriage was 16.1 ± 2.8 years. Maximum study subjects had stage III (44.4%) followed by stage II (23.5%), stage I (21.0%) and stage IV (11.1%). Preoperative CA-125 was >35 U/ml in 90.1% cases. Serum CA-125 was elevated at the advanced stage of ovarian cancer. Maximum study subjects had serous tumors (70.4%) followed by mucinous tumors (11.5%), endometrioid adenocarcinoma (7.4%), malignant teratoma (4.9%) and clear cell tumors (3.7%). Serum CA-125 had significant positive correlation with surgical stages of ovarian epithelial cancer.

Conclusion: Surgical stage of epithelial ovarian cancer significantly correlates with CA-125.

Bangladesh Med Res Counc Bull 2021; 47(2): 110-117

Downloads

Download data is not yet available.
Abstract
61
PDF
43

Downloads

Published

2022-05-17

How to Cite

Mohamed, Z., Begum, S. A., Mahmud, T., Amatullah, M., & Khanom, A. (2022). Correlation of Preoperative Level of Serum Ca125 with Surgical Staging of Ovarian Cancer: Serum CA125 level in ovarian cancer staging. Bangladesh Medical Research Council Bulletin, 47(2), 110–117. https://doi.org/10.3329/bmrcb.v47i2.57768

Issue

Vol. 47 No. 2 (2021)

Section

Research Papers

License

Copyright (c) 2021 Zulaikha Mohamed, Shirin Akter Begum, Tasfia Mahmud, Mehriban Amatullah, Afroza Khanom

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms.

Authors retain copyright and grant the journal right of first publication.

Creative Commons Licence
Articles in the Bangladesh Medical Research Council Bulletin are licensed under a Creative Commons Attribution 4.0 International License (CC-BY) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).