Vitamin D, Parathyroid Hormone and Insulin Resistance among Adults with Prediabetes

Vit. D, PTH and insulin prediabetes

Authors

  • Murshed Ahamed Khan Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
  • Md Fariduddin Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
  • Mohammad Masum Alam Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

DOI:

https://doi.org/10.3329/bmrcb.v47i3.59233

Keywords:

Parathyroid hormone, Vitamin D, Insulin resistance, Prediabetes

Abstract

Background: Several studies have found an inverse association among parathyroid hormone (PTH), vitamin D level, and insulin resistance (IR) causing prediabetes and diabetes. 
Objective: To assess the level of vitamin D, PTH, and insulin resistance among adults with prediabetes and determine the association of PTH vitamin D and insulin resistance (IR). 
Methods : This cross-sectional study was carried out in 140 newly detected adults with prediabetes according to ADA 2019 criteria. 25(OH) D cutoffs to define deficiency and insufficiency were used according to Endocrine Society (USA) criteria, Measurement of intact PTH, vitamin D and insulin (fasting) was done by chemiluminescent microparticle immunoassay (CMIA).
Results: In this study, most of the study population was 30 years and above (73.0%). The male-female ratio was 1:7, the majority of participants came from urban areas (81.0%). 37.0% had raised PTH and most of the participants (79.0%) were vitamin D deficient. A significant association was found between PTH and insulin resistance. Though it was observed that there was an increasing trend of insulin resistance across increasing severity of vitamin D deficiency but statistically it was not significant (p=0.74) 
Conclusion: Our study results demonstrate an inverse relationship between PTH and insulin resistance but there was no association had been found between vitamin D and insulin resistance in individuals with newly detected untreated prediabetes. The clinical significance of these observations warrants further study to explore these relationships more appropriately.

Bangladesh Med Res Counc Bull 2021; 47(3): 237-243

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Published

2022-07-28

How to Cite

Khan, M. A., Fariduddin, M., & Alam, M. M. (2022). Vitamin D, Parathyroid Hormone and Insulin Resistance among Adults with Prediabetes: Vit. D, PTH and insulin prediabetes. Bangladesh Medical Research Council Bulletin, 47(3), 237–243. https://doi.org/10.3329/bmrcb.v47i3.59233

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Section

Research Papers