Intravenous palonosetron and pethidine as prophylaxis of post spinal shivering: A comparative study

post anaestheasia shivering


  • Chandan Kumar Banik Department of Anaesthesiology, National Institute of Opthalmology & Hospital, Dhaka, Bangladesh
  • Prosanjit Mazumder Department of Anaesthesiology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh
  • Gopa Kundu Department of Gynaecological Oncology, Bangabanshu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
  • Shamim Ara Begum Department of Anaesthesiology, Imperial Hospital Ltd. Chottogram, Bangladesh



Palonosetron, Pethidine, postspinal shivering, subarachnoid block


Background: Post anaesthesia shivering is a frequent complication and associated with significant patient discomforts including metabolic changes.
Objectives: The study was designed to investigate the safety and efficacy of intravenous Palonosetron in prophylaxis of post spinal shivering in comparison to Pethidine in obstetric patients undergoing cesarean section under subarachnoid block.
Methods: In a prospective, randomised, double-blinded, controlled study, a total of ninety obstetric patients of ASA physical status I & II, aged 20-40 yrs, undergoing cesarean section received placebo (Group-C, n=30), Inj-Palonosetron 0.075mg (Group-O, n=30) and Inj. Pethidine (Group-P, n=30). These drugs were administered during intraoperative period just after cord clamp.
Result: Incidence of shivering, haemodynamic parameters were observed immediate after spinal anesthesia and then 5 min interval for 30 min throughout the intraoperative period. Responses of administered drugs were observed. Shivering was observed in 16 patients (53.3%) in group-C, 4 patients (13.3%) in group O, 8 patients (26.7%) in group P. The number of patients with a shivering grade 3 and 4 were very highly significant (p<0.001) in group C compared with other groups at 15 min and 20 min after block and highly significant (p<0.05) at 25 min and 30 min after block.
Conclusion: Palonosetron was found to be more effective than Pethidine in prophylaxis of post spinal shivering and also more haemodynamically stable.

Bangladesh Med Res Counc Bull 2021; 47(3): 289-294


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How to Cite

Banik, C. K., Mazumder, P. ., Kundu, G., & Begum, S. A. (2022). Intravenous palonosetron and pethidine as prophylaxis of post spinal shivering: A comparative study : post anaestheasia shivering. Bangladesh Medical Research Council Bulletin, 47(3), 289–294.



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