Assessment of Lipid Peroxidation and Antioxidant Status in a Sample of Prostate Cancer Patients in Bangladesh

Lipid peroxidation and antioxidant in prostate cancer

Authors

  • Ayatun Nesa Department of Laboratory Medicine, BIRDEM General Hospital, 122 Kazi Nazrul Islam Avenue, Dhaka, Bangladesh
  • Md Tahminur Rahman Department of Pathology, Anwer Khan Modern Medical College, Dhaka, Bangladesh
  • Yearul Kabir Department of Biochemistry & Molecular Biology, University of Dhaka, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bmrcb.v48i1.60656

Keywords:

Prostate cancer, Lipid peroxidation, Antioxidant, Malondialdehyde

Abstract

Background: Prostate cancer (PCa) is the second leading cause of cancer-related mortality in men. Oxidative stress has long been implicated in cancer development and progression.

Objective: To evaluate the lipid peroxidation and antioxidant status in a sample of prostate cancer patients in Bangladesh.

Methods: This case-control study included 207 histopathologically confirmed cases of prostate cancer and 200 age-matched healthy controls. After taking informed written consent, preset questioners were filled up, and about 5 ml of venous blood were collected with all aseptic precaution from each study subject for estimation of serum PSA, MDA, GST, SOD and erythrocyte reduced glutathione (GSH). All data were plotted in SPSS version 23, and different statistical analyses were done.

Results: In this study, the mean age of cases was 67.27±8.28 years, and among control, it was 62.17±6.77 years. Oxidative stress marker malondialdehyde was found significantly increased in prostate cancer patients than control. On the other hand, antioxidant erythrocyte reduced glutathione (GSH), and superoxide dismutase (SOD) were significantly reduced, and glutathione S transferase (GST) activity was significantly increased in prostate cancer patients, compared to control group.

Conclusion: This study revealed that overall oxidative stress was increased, and antioxidant levels were impaired in prostate cancer patients, which might play an important role in carcinogenesis. So, screening of oxidative stress and antioxidant status in the elderly male in a regular interval is recommended for early detection and proper management to prevent the aetiopathogenesis of prostate cancer.

Bangladesh Med Res Counc Bull 2022; 48(1): 21-26    

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Published

2022-09-05

How to Cite

Nesa, A. ., Rahman, M. . T. ., & Kabir, Y. . (2022). Assessment of Lipid Peroxidation and Antioxidant Status in a Sample of Prostate Cancer Patients in Bangladesh: Lipid peroxidation and antioxidant in prostate cancer. Bangladesh Medical Research Council Bulletin, 48(1), 21–26. https://doi.org/10.3329/bmrcb.v48i1.60656

Issue

Vol. 48 No. 1 (2022)

Section

Research Papers

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