Disease Activity States of Juvenile Idiopathic Arthritis in a Referral Centre in Bangladesh

Disease activity states of JIA patients

Authors

  • Mohammad Imnul Islam Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Sanjida Pervin Sonia Department of Paediatric Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh
  • Mujammel Haque Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Kamrul Laila Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh;
  • Manik Kumar Talukder Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Mohammed Mahbubul Islam Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Shahana Akther Rahman Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bmrcb.v48i1.60659

Keywords:

Active disease, Clinical remission on medication, Clinical remission off medication, Enthesitis related arthritis

Abstract

Background: The clinical course of juvenile idiopathic arthritis (JIA) is unpredictable and characterised by periods of disease inactivity followed by active disease states with on or off medication.

Objectives: To assess the disease activity state of JIA patients in our centre and compare them with other available reports. Methods: A retrospective cohort study carried out in the department of paediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from July 2010 to December 2019 . A total of 1782 JIA patients, fulfilling ILAR criteria, who have completed at least three years of follow-up were enrolled in this study. Disease activity states were assessed according to Wallace’s criteria.

Results: The mean age at presentation of disease was 8.33±4.8 years and M:F ratio was 1.4:1. Enthesitis related arthritis (ERA) was the commonest (38.0%) subtype, followed by systemic arthritis and RF–ve polyarthritis. Eighty-three percent of the JIA patients were treated with MTX followed by sulfasalazine (30.0%) and leflunamide (13.0%). Only 12.0% received biological agents and other drugs including thalidomide and tofacitinib. At 3 years follow-up, 39.2% had active disease and 60.7% had non-active disease states. Inactive disease states, clinical remission on medication (CRM) and clinical remission off medication (CR) were maintained by 27.1%, 20.1 %, and 13.3% of JIA patients respectively.

Conclusion: Most (60.7%) of the JIA patients maintained CRM, CR and inactive disease states. Active disease was found in 39.2% of JIA patients. The highest rate of remission was achieved in persistent oligoarthritis cases. RF+ve polyarthritis patients had the lowest remission rate.

Bangladesh Med Res Counc Bull 2022; 48(1): 41-47       

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Published

2022-09-05

How to Cite

Islam, M. I., Sonia, S. P., Haque, M., Laila, K. ., Talukder , M. K. ., Islam , M. M. ., & Rahman, S. A. . (2022). Disease Activity States of Juvenile Idiopathic Arthritis in a Referral Centre in Bangladesh: Disease activity states of JIA patients. Bangladesh Medical Research Council Bulletin, 48(1), 41–47. https://doi.org/10.3329/bmrcb.v48i1.60659

Issue

Vol. 48 No. 1 (2022)

Section

Research Papers

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