Autism Spectrum Disorder in Children with Epilepsy: A Case-Control Study in a Tertiary Care Hospital in Bangladesh

Autism Spectrum Disorder in Children

Authors

  • Mohammad Monir Hossain Department of Paediatric Neurology, National institute of Neurosciences and Hospital, Dhaka, Bangladesh.
  • Shaheen Akhter Department of Paediatric Neurology and Director, Institute of Paediatric Neurodisorder and Autism (IPNA), Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
  • Muhammad Mizanur Rahman Department of Paediatric Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
  • Kanij Fatema Department of Paediatric Neurology and Deputy Director, Institute of Neurodisorder and autism (IPNA), Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
  • Mohammad SI Mullick Department of Psychiatry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
  • Ayesha Siddika Departmetu of Community Medicine, National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh.
  • Mohammad Zahir Uddin Department of Paediatrics, Jamalpur Sadar Hospital, Jamalpur, Bangladesh.

DOI:

https://doi.org/10.3329/bmrcb.v48i2.62296

Keywords:

Autism spectrum disorders (ASD), Epilepsy, Diagnostic and Statistical Manual of Mental Disorders (DSM-V), Neurodevelopmental disorder

Abstract

Background: Autism spectrum disorders (ASD), a neurodevelopmental deficit, is often associated with epilepsy. Previous literature suggested that ASD and epilepsy share a common pathophysiological basis. Considering the scarcity of studies regarding ASD in children with epilepsy, this study was conducted with an aim to evaluate the association of ASD with epilepsy.

Materials and Methods: This case-control study was conducted in the Department of Pediatric Neurology, Institute of Paediatric Neurodisorder and Autism, Bangabandhu Sheikh Mujib Medical University, Dhaka, from September’ 2018 to December 2019. In total, 68 epileptic children, age ranged from five to 16 years, were enrolled as case. Similar number of non-epileptic, age, sex and socio-demographic status matched children were enrolled as control. Parent, teacher and self version of Bangla Development and Well-Being Assessment were used to assess the psychiatric disorders particularly ASD and diagnosis was assigned as Diagnostic and Statistical Manual of Mental Disorders (DSM-V).

Results: The mean age of cases and controls were 9.66±3.13 and 9.26±3.11 years respectively with slight male predominance in both groups (64.7 and 57.35%, respectively). Focal seizure was predominant seizure type (51.5%) among cases. Higher proportion of psychiatric illness was found among the cases compared to controls (83.82 vs 20.59%; p<0.001). Neurodevdevelopmental and emotional disorders were significantly more frequent among cases than controls (29.42 vs 1.5%, and 50 vs 8.82%, respectively, p value <0.001). ASD was prevalent among 8.83% epileptic children, while none of the controls had ASD. Most common types of seizure in ASD children was focal epilepsy .

Conclusions: This study observed the significant association of ASD with epilepsy in studied children. However, further larger multicenter study is recommended.

Bangladesh Medical Res Counc Bull 2022; 48: 112-119

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Published

2023-05-28

How to Cite

Hossain, M. M., Akhter, S., Mizanur Rahman, M., Fatema, K., SI Mullick, M., Siddika, A., & Zahir Uddin, M. (2023). Autism Spectrum Disorder in Children with Epilepsy: A Case-Control Study in a Tertiary Care Hospital in Bangladesh: Autism Spectrum Disorder in Children. Bangladesh Medical Research Council Bulletin, 48(2), 112–119. https://doi.org/10.3329/bmrcb.v48i2.62296

Issue

Vol. 48 No. 2 (2022)

Section

Research Papers

License

Copyright (c) 2022 Mohammad Monir Hossain, Shaheen Akhter, Muhammad Mizanur Rahman, Kanij Fatema, Mohammad SI Mullick, Ayesha Siddika, Mohammad Zahir Uddin

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