Association of Pre-operative Serum Albumin Level with Post-operative Complications in Patients Undergoing Primary Cytoreductive Surgery for Epithelial Ovarian Carcinoma (EOC)

Complications of Epithelial Ovarian Cytoreductive Surgery

Authors

  • Mst Farhana Tarannum Khan Khan Dept. of Gynaecological Oncology National Institute of Cancer Research & Hospital (NICR&H), Mohakhali, Dhaka.
  • Chowdhury Shamima Sultana Dept. of Gynaecological Oncology National Institute of Cancer Research & Hospital (NICR&H), Mohakhali, Dhaka.
  • Nasrin Hossain Dept. of Gynaecological Oncology National Institute of Cancer Research & Hospital (NICR&H), Mohakhali, Dhaka.
  • Begum Rokeya Anwar Dept. of Gynaecological Oncology National Institute of Cancer Research & Hospital (NICR&H), Mohakhali, Dhaka.
  • Mahenaj Afroz Dept. of Gynaecological Oncology National Institute of Cancer Research & Hospital (NICR&H), Mohakhali, Dhaka.
  • Salma Akter Walida Dept. of Gynaecological Oncology National Institute of Cancer Research & Hospital (NICR&H), Mohakhali, Dhaka.

DOI:

https://doi.org/10.3329/bmrcb.v50i1.68856

Keywords:

Hypoalbuminemia, Epithelial ovarian cancer Primary cytoreductive surgery, Postoperative complications

Abstract

Background: Epithelial ovarian carcinoma (EOC) is the most lethal of all the gynaecological malignancies. Primary cytoreductive surgery is one of the mainstays in the management of women with epithelial ovarian carcinoma. Because of the silent nature of the condition, most patients present in advanced stage of the disease and malnutrition is common in them. Thus, preoperative evaluation of serum albumin in patients with EOC in regards to primary cytoreductive surgery seems to be of particular importance.

Objective: The aim of this study was to evaluate the association between preoperative serum albumin level with postoperative complications up to 30-th postoperative day in patients with EOC underwent primary cytoreductive surgery.

Methods: This is a cross sectional study conducted on 60 patients with EOC who underwent primary cytoreductive surgery in the Gynaecological Oncology Department of NICRH, Mohakhali, Dhaka from March 2019 to February 2020. Hypoalbuminemia was defined as a serum albumin level

Methods: This is a cross sectional study conducted on 60 patients with EOC who underwent primary cytoreductive surgery in the Gynaecological Oncology Department of NICRH, Mohakhali, Dhaka from March 2019 to February 2020. Hypoalbuminemia was defined as a serum albumin level <3.5g/dl. Postoperative complications were recorded up to 30th postoperative day. Data were analysed by Chi-squared test or the Fischer exact test as feasible and p-value was calculated. P-value <0.05 was considered statistically significant.

Results: The median age was 50 years (range: 21 to 68 years). Out of total 60 patients, 25(42%) had hypoalbuminemia (<3.5g/dl) and 35(58%) had normal albumin (≥3.5g/dl). The mean (±SD) albumin value was 3.18 (±0.12) and 3.97 (±0.36) g/dl in hypoalbuminemia and normal albumin group respectively. Patients with hypoalbuminemia suffered more complications compared to normoalbuminemic patients (p 0.001) and longer duration of hospital stay (p 0.039).

Conclusion: Preoperative hypoalbuminemia in patients with EOC who will undergo primary cytoreductive surgery is an important predictor of 30-day postoperative complications. Identification of this subset and preoperative optimization of nutritional status may improve surgical outcome.

Bangladesh Med Res Counc Bull 2024; 50: 15-24

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Published

2024-04-01

How to Cite

Khan, M. F. T. K., Sultana, C. S., Hossain, N., Anwar, B. R., Afroz, M., & Walida, S. A. (2024). Association of Pre-operative Serum Albumin Level with Post-operative Complications in Patients Undergoing Primary Cytoreductive Surgery for Epithelial Ovarian Carcinoma (EOC): Complications of Epithelial Ovarian Cytoreductive Surgery. Bangladesh Medical Research Council Bulletin, 50(1), 15–24. https://doi.org/10.3329/bmrcb.v50i1.68856

Issue

Vol. 50 No. 1 (2024)

Section

Research Papers

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Copyright (c) 2024 Mst Farhana Tarannum Khan Khan; Chowdhury Shamima Sultana, Nasrin Hossain, Begum Rokeya Anwar, Mahenaj Afroz, Salma Akter Walida

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