Association Between Lymphovascular Space Invasion and Preoperative CA-125 Antigen and Fibrinogen in Patients with Endometrial Carcinoma

CA-125 Antigen and Fibrinogen in Patients with Endometrial Carcinoma

Authors

  • Samina Sultana Department of (OBGYN) & Gynaecological Oncology, Dhaka Medical College & Hospital, Dhaka
  • Sabera Khatun Department of Gynecological Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Shirin Akter Begum Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Mehriban Amatullah Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Tasfia Mahmud Sirajul Islam Medical College, Dhaka.
  • Marzina Faruq Department of Obst. & Gynae, 100 bed Upazila Health Complex, Sashiani, Gopalgonj.
  • Zakia Sultana Saheed M. Monsur Ali Medical College Hospital, Sirajganj
  • Towhida Naznin 250 beds district hospital, Minshiganj.

DOI:

https://doi.org/10.3329/bmrcb.v50i1.69717

Keywords:

Endometrial Carcinoma, Lymphovascular Space Invasion, CA-125 Antigen, Fibrinogen

Abstract

Background: Lymphovascular space invasion (LVSI) is the presence of tumor cells in a vascular space lined by endothelium. It is the crucial first step to tumor metastases. It has been suggested that LVSI is the strongest predictor of lymph node metastases, relapse of disease, and poor survival in endometrial carcinoma. Lymphovascular space invasion is an important predictor of lymph node involvement in endometrial carcinoma. Studies showed that LVSI can be predicted preoperatively by some biomarkers, which may be helpful regarding lymphadenectomy per-operatively in patients with endometrial carcinoma.

Objective: The aim of this study was to predict the risk of lymphovascular space invasion (LVSI) in women with endometrial carcinoma.

Methods: This is a cross-sectional analytical study done in the gynecological Oncology Department of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, between September 2018 and August 2019. A total of 35 patients with endometrial carcinoma admitted for surgery at the Department of Gynecological Oncology, BSMMU, were included in this study.

Results: Among 35 patients with endometrial carcinoma, 12 patients were positive for LVSI, and 23 patients were negative for LVSI. It was found that depth of myometrial invasion, FIGO tumor stage, histological tumor type, tumor grade, and positive pelvic lymph nodes were associated with LVSI (p0.05). Receiver operating characteristic (ROC) curves revealed that the threshold values of CA- 125 and fibrinogen correlated with LVSI were 34.15 U/mL and 300 mg/dl, respectively. Statistical analysis showed that CA-125 >34 U/mL (p=0.026) and fibrinogen ≥300 mg/dl (p<0.001) were significantly associated with LVSI.

Conclusion: There is a positive association between LVSI and preoperative serum CA-125 antigen and plasma fibrinogen in endometrial carcinoma patients. So, these biomarkers may help make decisions regarding lymphadenectomy during surgery for endometrial carcinoma patients.

Bangladesh Med Res Counc Bull 2024; 50: 40-47

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Published

2024-04-01

How to Cite

Sultana, S., Khatun, S., Begum, S. A., Amatullah, M., Mahmud, T., Faruq, M., Sultana, Z., & Naznin, T. (2024). Association Between Lymphovascular Space Invasion and Preoperative CA-125 Antigen and Fibrinogen in Patients with Endometrial Carcinoma: CA-125 Antigen and Fibrinogen in Patients with Endometrial Carcinoma. Bangladesh Medical Research Council Bulletin, 50(1), 40–47. https://doi.org/10.3329/bmrcb.v50i1.69717

Issue

Vol. 50 No. 1 (2024)

Section

Research Papers

License

Copyright (c) 2024 Samina Sultana; Sabera Khatun, Shirin Akter Begum, Mehriban Amatullah, Tasfia Mahmud, Marzina Faruq, Zakia Sultana, Towhida Naznin

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