Association of Serum FT3 with Severity of Heart Failure and it’s Correlation with NT-proBNP

FT3, Heart Failure Severity, and NT-proBNP

Authors

  • Siddika Sanjida Department of Biochemistry, International Medical college, Gushulia, Sataish, Tongi, Gazipur.
  • Nowrose Jahan Department of biochemistry, Medical college for women & Hospital, Dhaka
  • Sk Faieq Siddique Department of gastroenterology, Enam Medical college & Hospital., Savar, Dhaka
  • Tasnim Tabassum Progga Department of biochemistry, Asgar Ali Medical college, Gandaria, Dhaka-1204
  • Rifat Ara Chayan Department of biochemistry, Sheikh Sayera khatun medical college, Gopalganj.
  • Masrufa Gulshan Department of biochemistry, Chandpur Medical College, Chandpur

DOI:

https://doi.org/10.3329/bmrcb.v50i02.76857

Keywords:

Heart failure patients, serum FT3, serum TSH, serum NT-proBNP

Abstract

Background: Heart failure is a global health emergency affecting millions of people worldwide and is increasing in prevalence. NT-proBNP is a hormone that is a marker of severity and prognosis of heart failure. Thyroid hormone has an important regulatory impact on the heart. Altered thyroid function specially triiodothyronine and increase NT-proBNP are highly prevalent in heart failure patients without apparent thyroid diseases.

 Objectives: To evaluate the association of serum FT3 with heart failure severity and its correlation with NT-proBNP as a potential marker.

 Methods: A cross-sectional analytical study was conducted at the Department of Biochemistry, Sir Salimullah Medical College (SSMC), over a 12-month period following ethical approval. A total of 110 clinically diagnosed heart failure subjects were enrolled based on inclusion and exclusion criteria. Written informed consent was obtained from patients and detailed histories, clinical examinations and Serum FT3, serum TSH and serum NT-proBNP were performed. Data was collected using a semi-structured questionnaire and Statistical analysis was done by using SPSS version 22.0.

Results: Serum FT3 level was significantly lower among heart failure patients with high NT-proBNP but the mean value of serum TSH was normal. Low FT3 level is associated with more severe heart failure patients having high NT-proBNP levels.

Conclusion: Serum FT3 has an inverse relation with NT-proBNP in patients with heart failure. As low FT3 associated with severe heart failure patients with high NT-proBNP, low FT3 could be a potential marker for heart failure severity.

Bangladesh Med Res Counc Bull 2024; 50: 104-110  

Downloads

Download data is not yet available.
Abstract
42
PDF
33

Downloads

Published

2025-07-20

How to Cite

Sanjida, S., Jahan, N., Siddique, S. F., Progga, T. T., Chayan, R. A., & Gulshan, M. (2025). Association of Serum FT3 with Severity of Heart Failure and it’s Correlation with NT-proBNP: FT3, Heart Failure Severity, and NT-proBNP. Bangladesh Medical Research Council Bulletin, 50(2), 104–110. https://doi.org/10.3329/bmrcb.v50i02.76857

Issue

Vol. 50 No. 2 (2024)

Section

Research Papers

License

Copyright (c) 2024 Siddika Sanjida, Nowrose Jahan, Sk Faieq Siddique, Tasnim Tabassum Progga, Rifat Ara Chayan, Masrufa Gulshan

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms.

Authors retain copyright and grant the journal right of first publication.

Creative Commons Licence
Articles in the Bangladesh Medical Research Council Bulletin are licensed under a Creative Commons Attribution 4.0 International License (CC-BY) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).