Association of Interatrial Septal Thickness with Severity of Coronary Artery Diseases
DOI:
https://doi.org/10.3329/bmrcb.v51i1.80399Keywords:
Interatrial septal thickness, severity of coronary artery disease, gensini scoreAbstract
Background: Epicardial adipose tissue is the main determinant of interatrial septum thickness (IST) and it is also a true marker of cardiac adiposity. The relationship of interatrial septal thickness as a marker cardiac adiposity with severity of coronary artery disease (CAD) is not thoroughly investigated in our population.
Objectives: This study was conducted to evaluate the association of interatrial septal thickness (IST) with severity of coronary artery disease.
Methods: This cross-sectional study was conducted in the National Institute of Cardiovascular Disease (NICVD), Dhaka from April 2016 to March 2017. A total of 100 patients with coronary artery disease (CAD) who agreed to undergo coronary angiography were selected by non probability sampling. Interatrial septal thickness (IST) was measured using bidimensional echocardiography. On the basis of IST, study subjects were divided into two groups: 50 patients of CAD with IST ≥14.2 mm were designated as Group I (Thick) and 50 patients of CAD with IST<14.2 mm were designated as Group II (Thin). During angiogram coronary artery disease severity was assessed by Gensini score. Then the collected data were analysed. Categorical variables were analyzed by chi-square test. Quantitative variables were analyzed by unpaired t-test. Correlation between IST and angiographic severity (gensini score) was measured by Spearman’s rank correlation coefficient test. Odds ratio (OR) and logistic regression test were done to identify the factors associate with CAD severity. P<0.05 was considered as significant. Statistical analyses were performed with SPSS, version 16.0 (SPSS Inc).
Results: Severe CAD patients were found significantly more in Group I (thick) than in Group II (thin) [78% vs 14%, p<0.001]. IST showed a moderate positive correlation with Gensini score (r=0.58). Univariate and multivariate analysis revealed that dyslipidemia, diabetes mellitus, high waist circumference and increased IST were independently significant predictors of severe CAD. Out of them increased IST was found be the strongest independent predictor of the severity of CAD with odd ratio 9.8 (95% CI 2.17 - 44.4).
Conclusion: The study concludes that increased interatrial septal thickness (IST) is associated with severe coronary artery disease (CAD). So, severe CAD may be predicted by measuring the interatrial septal thickness.
Bangladesh Medical Res Counc Bull 2025;51(1):25-32
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Copyright (c) 2025 Shubhra Chakaraborty, Amal Kumar Choudhury, Sabina Hashem, Md. Zillur Rahman, Md Abdul Matin, Ashraf Ur Rahman Tamal
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