To compare the efficacy of triple therapy with furazolidone, amoxicillin and omeprazole for two weeks and three weeks in the eradication of <i>Helicobacter pylori</i> in Bangladeshi duodenal ulcer patients

Authors

  • SK Saha Department of Gastroenterology, Sir Salimullah Medical College & Mitford Hospital, Dhaka
  • SK Saha Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • H Masud Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • N Islam Department of Pathology, National Institute of Ophthalmology, Sher-e-Bangla Nagar, Dhaka
  • ASMA Raihan Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • PK Roy Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • M Hasan Department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/bmrcb.v37i3.9118

Keywords:

comparison, efficacy, triple therapy, furazolidone, amoxicillin, omeprazole, eradication, <i>Helicobacter pylori</i>, Bangladeshi, duodenal ulcer patients

Abstract

Helicobacter pylori eradication is the mainstay in the treatment of Helicobacter pylori associated peptic ulcer disease. Furazolidone was tried in several developing countries and showed good results in some trials. Increasing the duration of treatment has been shown to improve the eradication rate. This study was done to compare the efficacy of triple therapy for two weeks (Group–A) and three weeks (Group–B) consisting of omeprazole 20 mg b.d. amoxicillin 1gm b.d. and furazolidone 200 mg b.d. in the eradication of Helicobacter pylori in duodenal ulcer patient. A total of 70 duodenal ulcer patients with Helicobacter pylori infection were included in the study. Healing of duodenal ulcer was assessed three months after the end of treatment and at the same time Helicobacter pylori eradication assessed by Campylobacter Like Organism (CLO) test and histology. In group–A, duodenal ulcer was healed in 17(58.62%) patients and Helicobacter pylori was eradicated in 15(52%) patients. In group-B, duodenal ulcer was healed in 19(61.30%) patients and Helicobacter pylori was eradicated in 18(58%) patients. Healing of duodenal ulcer was not significantly different between two groups. Eradication of Helicobacter pylori was also not significantly different between two groups.

DOI: http://dx.doi.org/10.3329/bmrcb.v37i3.9118

BMRCB 2011; 37(3): 83-87

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How to Cite

Saha, S., Saha, S., Masud, H., Islam, N., Raihan, A., Roy, P., & Hasan, M. (2011). To compare the efficacy of triple therapy with furazolidone, amoxicillin and omeprazole for two weeks and three weeks in the eradication of <i>Helicobacter pylori</i> in Bangladeshi duodenal ulcer patients. Bangladesh Medical Research Council Bulletin, 37(3), 83–87. https://doi.org/10.3329/bmrcb.v37i3.9118

Issue

Vol. 37 No. 3 (2011)

Section

Research Papers

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