Capacity of Non Ionic and Ionic Surfactants for Solubilisation of Paracetamol

Authors

  • Tamanna Rahaman Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342
  • Jannatul Fardous Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342
  • Faria Farzana Perveen Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342
  • Sakina Sultana Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342

DOI:

https://doi.org/10.3329/bpj.v16i1.14498

Keywords:

PVP K-30, PEG 6000, Tween 80, Sodium lauryl sulphate, Solubilising capacity, Paracetamol

Abstract

The present study was conducted to investigate the solubilising capacity of polyvinylpyrrollidone (PVP K-30), Polyethylene glycol (PEG 6000), Polysorbate (Tween 80) and Sodium lauryl sulphate (SLS) for paracetamol. In our study, PVP K-30 exhibited 5 times, Tween 80 showed 3 times and SLS displayed 2 times higher solubilising capacity than water. Here, PVP K-30 exhibited the highest solubilising capacity and the value was 6.36 ± 0.063 (mg /ml), whilst PEG 6000 in the same study failed to show any significant increase (p> 0.05, unpaired t-test, two-tailed).

DOI: http://dx.doi.org/10.3329/bpj.v16i1.14498

Bangladesh Pharmaceutical Journal 16(1): 77-80, 2013

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Published

2013-04-08

How to Cite

Rahaman, T., Fardous, J., Perveen, F. F., & Sultana, S. (2013). Capacity of Non Ionic and Ionic Surfactants for Solubilisation of Paracetamol. Bangladesh Pharmaceutical Journal, 16(1), 77–80. https://doi.org/10.3329/bpj.v16i1.14498

Issue

Vol. 16 No. 1 (2013)

Section

Articles