Evaluation of Cardiovascular Activity of an Ayurvedic Product ‘Mrityunjay’ in Rat Model

Authors

  • Most Shammi Rahman Department of Pharmacy, State University of Bangladesh, Dhanmondhi, Dhaka
  • Shahana Jahan Department of Pharmacy, State University of Bangladesh, Dhanmondhi, Dhaka
  • Kamrun Nahar Department of Pharmacy, State University of Bangladesh, Dhanmondhi, Dhaka
  • Nazia Islam Department of Pharmacy, State University of Bangladesh, Dhanmondhi, Dhaka
  • Danis Rahman Department of Pharmacy, Jahangirnagar University, Savar, Dhaka
  • Ridwan Bin Rashid Department of Microbiology, University of Dhaka, Dhaka-1000
  • Abu Asad Chowdhury Department of Microbiology, University of Dhaka, Dhaka-1000
  • Rebecca Banoo Department of Microbiology, University of Dhaka, Dhaka-1000
  • Mohammad Shah Amran Department of Pharmaceutical Chemistry, Faculty of pharmacy, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/bpj.v16i1.14503

Keywords:

Ayurvedic, Mrityunjay, ECG, Cardiovascular disease, Ketamine

Abstract

Ayurvedic system of medicine is a major component of indigenous systems of medicine in Bangladesh. We used an Ayurvedic drug Mrityunjay which is traditionally used for high blood pressure, heart diseases and heartquake. We measured the electrocardiographical (ECG) parameters using an ECG machine (Vet 300, EDAN, China) in rat model before and after administration of the test drug. We observed that, Mrityunjay at high doses (800 ?g/Kg, 1600?g/kg, 3200?g/kg) produced heart blocks and other arrhythmias, but in normal dose (200?g/Kg) it has no serious untoward effects on cardiac muscle.

DOI: http://dx.doi.org/10.3329/bpj.v16i1.14503

Bangladesh Pharmaceutical Journal 16(1): 99-105, 2013

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Published

2013-04-08

How to Cite

Rahman, M. S., Jahan, S., Nahar, K., Islam, N., Rahman, D., Rashid, R. B., Chowdhury, A. A., Banoo, R., & Amran, M. S. (2013). Evaluation of Cardiovascular Activity of an Ayurvedic Product ‘Mrityunjay’ in Rat Model. Bangladesh Pharmaceutical Journal, 16(1), 99–105. https://doi.org/10.3329/bpj.v16i1.14503

Issue

Vol. 16 No. 1 (2013)

Section

Articles