Thrombolytic and Cytotoxic Activities of Terminalia bellerica Roxb.

Authors

  • M Sekendar Ali Department of Pharmacy, International Islamic University Chittagong, Chittagong-4203
  • Kazi Omar Faruq Department of Pharmacy, International Islamic University Chittagong, Chittagong-4203
  • Atiqul Islam Department of Pharmacy, International Islamic University Chittagong, Chittagong-4203
  • AMM Nurullah Department of Pharmacy, International Islamic University Chittagong, Chittagong-4203
  • Kazi Ashfak Ahmed Chowdhury Department of Pharmacy, International Islamic University Chittagong, Chittagong-4203
  • Mohammed Abu Sayeed Department of Pharmacy, International Islamic University Chittagong, Chittagong-4203

DOI:

https://doi.org/10.3329/bpj.v16i2.22293

Keywords:

Thrombolytic, Cytotoxic, Clot lysis, Terminalia bellerica

Abstract

The present study was designed to investigate the thrombolytic activity and cytotoxic potential of the methanolic extract of bark of Terminalia bellerica Roxb. The cytotoxicity was assessed with the brine shrimp lethality bioassay and thrombolytic effect with human blood. The brine shrimp lethality bioassay was used to evaluate cytotoxicity (LC50 = 3.21 ?g/ml) compared to vincristine of sulphate (LC50 = 0.512 ?g /ml). It was also evaluated as thrombolytic agent as compared to streptokinase. It has significant thrombolytic activity (32.95%) compared to standard streptokinase (70%).

DOI: http://dx.doi.org/10.3329/bpj.v16i2.22293

Bangladesh Pharmaceutical Journal 16(2): 131-135, 2013

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Published

2015-02-20

How to Cite

Ali, M. S., Faruq, K. O., Islam, A., Nurullah, A., Chowdhury, K. A. A., & Sayeed, M. A. (2015). Thrombolytic and Cytotoxic Activities of Terminalia bellerica Roxb. Bangladesh Pharmaceutical Journal, 16(2), 131–135. https://doi.org/10.3329/bpj.v16i2.22293

Issue

Vol. 16 No. 2 (2013)

Section

Articles