Nigella sativa Oil Potentiates the Effects of Pioglitazone on Long Term Alloxan-Induced Diabetic Rats

Authors

  • AFM Towheedur Rahman Department of Pharmacy, University of Rajshahi, Rajshahi-6205
  • Md Saiful Islam Department of Pharmacy, University of Rajshahi, Rajshahi-6205
  • Md Hazrat Ali Department of Pharmacy, University of Rajshahi, Rajshahi-6205
  • AHM Khurshid Alam Department of Pharmacy, University of Rajshahi, Rajshahi-6205
  • Md Aziz Abdur Rahman Department of Pharmacy, University of Rajshahi, Rajshahi-6205
  • Md Golam Sadik Department of Pharmacy, University of Rajshahi, Rajshahi-6205
  • Mamunur Rashid Department of Pharmacy, University of Rajshahi, Rajshahi-6205

DOI:

https://doi.org/10.3329/bpj.v16i2.22296

Keywords:

Nigella sativa oil, Pioglitazone, Diabetes, Combination drugs, Islets of Langerhans

Abstract

The present study was designed to investigate the effects of combination of Nigella sativa oil and pioglitazone on long-term alloxan-induced diabetic rats. In short-term (two weeks) alloxan-induced diabetic rats, N. sativa oil (NSO) reduced significant amount of glucose in blood, TC, TG and LDL-C and increased significant amount of HDL-C compared to diabetic rats. However, pathological changes of pancreass Islets of Langerhans were observed after long-term (four weeks) induction of alloxan in rats. Administration of NSO recovered Langerhans cells from shrinkage whereas pioglitazone displayed slight recovery. But the combination therapy showed complete recovery of Langerhans cells as compared with diabetic rats. Combination of drugs significantly reduced the TC, TG and LDL-C level as well as increased significant amount of HDL-C level to the normal level. Combination also increased DPPH free radical scavenging activity compared with diabetic rats. The results suggest that treatment with combination therapy was more effective than mono-therapy for preventing diabetes as N. sativa oil potentiates the effects of pioglitazone on long term alloxan-induced diabetic rats.

DOI: http://dx.doi.org/10.3329/bpj.v16i2.22296

Bangladesh Pharmaceutical Journal 16(2): 143-151, 2013

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Published

2015-02-20

How to Cite

Rahman, A. T., Islam, M. S., Ali, M. H., Alam, A. K., Rahman, M. A. A., Sadik, M. G., & Rashid, M. (2015). Nigella sativa Oil Potentiates the Effects of Pioglitazone on Long Term Alloxan-Induced Diabetic Rats. Bangladesh Pharmaceutical Journal, 16(2), 143–151. https://doi.org/10.3329/bpj.v16i2.22296

Issue

Vol. 16 No. 2 (2013)

Section

Articles