Fabrication and Evaluation of Sustained Release Mucoadhesive Losartan Potassium Matrix Tablets

Authors

  • Md Emdadul Hasan Mukul Department of Pharmacy, Noakhali Science and Technology University Sonapur, Noakhali-3814
  • Sayed Koushik Ahmed Department of Pharmacy, Noakhali Science and Technology University Sonapur, Noakhali-3814
  • Mariyum Akter Department of Pharmacy, Noakhali Science and Technology University Sonapur, Noakhali-3814
  • Mohammad Salim Hossain Department of Pharmacy, Noakhali Science and Technology University Sonapur, Noakhali-3814

DOI:

https://doi.org/10.3329/bpj.v16i2.22297

Keywords:

Mucoadhesion, Losartan Potassium, Retention time, Release kinetics

Abstract

Sustained release matrix tablets of Losartan potassium were prepared with different types of mucoadhesive polymers e.g. Hydroxypropylmethyl cellulose (HPMC), Sodium carboxymethyl cellulose (Na-CMC) and Methyl cellulose (MC). The tablets were prepared by direct compression method and then were subjected to in-vitro drug dissolution for 8 hours in phosphate buffer of pH 6.8. The mucoadhesive property was investigated in terms of retention time by wash-off method. Irrespective of amount of polymer, mucoadhesive strength of MC was proved to be maximum where HPMC and Na-CMC showed moderate or poor mucoadhesive strength. Drug release from all formulations followed Higuchi release mechanism.

DOI: http://dx.doi.org/10.3329/bpj.v16i2.22297

Bangladesh Pharmaceutical Journal 16(2): 153-157, 2013

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Published

2015-02-20

How to Cite

Mukul, M. E. H., Ahmed, S. K., Akter, M., & Hossain, M. S. (2015). Fabrication and Evaluation of Sustained Release Mucoadhesive Losartan Potassium Matrix Tablets. Bangladesh Pharmaceutical Journal, 16(2), 153–157. https://doi.org/10.3329/bpj.v16i2.22297

Issue

Vol. 16 No. 2 (2013)

Section

Articles