Evaluation of in vitro Interaction of Metformin with Ibuprofen in Aqueous Medium

Authors

  • Shuvashis Saha Department of Pharmaceutical Chemistry, faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Rehana Begum Department of Pharmaceutical Chemistry, faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Asma Rahman Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000
  • Md Zakir Sultan Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000
  • Md Shah Amran Department of Pharmaceutical Chemistry, faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Amjad Hossain Department of Pharmaceutical Chemistry, faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bpj.v16i2.22303

Keywords:

Metformin, ibuprofen, interaction, complexation

Abstract

The purpose of the present study was to investigate the in vitro complex formation and to study the nature and strength of complexes which could be formed due to interaction of metformin with ibuprofen. Metformin is an antidiabetic drug and ibuprofen is a non steroidal anti-inflammatory drug (NSAID). The in vitro interaction of metformin with ibuprofen was studied at room temperature and at different pH conditions. The studies were performed by UV-Visible spectrophotometry, conductometry and reversed - it was phase high performance liquid chromatography (RP-HPLC). It was found that metformin formed stable 1:1 complex with ibuprofen. The interaction may greatly influence the activity of these molecules.

DOI: http://dx.doi.org/10.3329/bpj.v16i2.22303

Bangladesh Pharmaceutical Journal 16(2): 189-194, 2013

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Published

2015-02-20

How to Cite

Saha, S., Begum, R., Rahman, A., Sultan, M. Z., Amran, M. S., & Hossain, M. A. (2015). Evaluation of in vitro Interaction of Metformin with Ibuprofen in Aqueous Medium. Bangladesh Pharmaceutical Journal, 16(2), 189–194. https://doi.org/10.3329/bpj.v16i2.22303

Issue

Vol. 16 No. 2 (2013)

Section

Articles