Review on Chemistry and Bioactivities of Secondary Metabolites from Some Medicinal Plants and Microbes of Bangladesh

Authors

  • Mohammad A Rashid Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad R Haque Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Al Amin Sikder Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Abu A Chowdhury Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad S Rahman Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Choudhury M Hasan Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bpj.v17i1.22307

Keywords:

Medicinal Plants, secondary metabolites, antioxidant, antidiabetic, HIV-inhibitory activity

Abstract

Plants and microorganisms, being the major source of many drugs, have attracted scientists from ancient times. However, until recently an insignificant part of the plants and some microorganisms have scientifically been evaluated for their medicinal values. The present study was undertaken to discover new drug candidates from natural sources. Extensive chemical studies with 60 medicinal plants and several microbial strains of Bangladesh have resulted in the isolation and characterization of 150 compounds, including 50 new molecules. Terpenoids and alkaloids were the major constituents among the isolated compounds. The crude extractives and several purified molecules demonstrated statistically significant inhibition of growth of microorganisms, antioxidant, antidiabetic and HIV-inhibitory activities. Usnic acid, a lead compound isolated from the lichen, Parmelia kamtschandalis, showed potent antimicrobial activity, whereas dehydroaltenusin obtained from a Streptomyces sp. exhibited significant HIV-inhibitory effects.

DOI: http://dx.doi.org/10.3329/bpj.v17i1.22307

Bangladesh Pharmaceutical Journal 17(1): 1-17, 2014

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Published

2015-02-20

How to Cite

Rashid, M. A., Haque, M. R., Sikder, M. A. A., Chowdhury, A. A., Rahman, M. S., & Hasan, C. M. (2015). Review on Chemistry and Bioactivities of Secondary Metabolites from Some Medicinal Plants and Microbes of Bangladesh. Bangladesh Pharmaceutical Journal, 17(1), 1–17. https://doi.org/10.3329/bpj.v17i1.22307

Issue

Vol. 17 No. 1 (2014)

Section

Articles