In vitro Antioxidant, Cytotoxic and Membrane Stabilizing Activities of Bauhinia acuminata L.

Authors

  • Mohammad Firoz Khan Department of Pharmacy, State University of Bangladesh, Dhaka- 1205
  • Rabeya Islam Shilpi Department of Pharmacy, State University of Bangladesh, Dhaka- 1205
  • Ridwan Bin Rashid Department of Microbiology, University of Dhaka, Dhaka- 1000
  • Mohammad A Rashid Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka- 1000

DOI:

https://doi.org/10.3329/bpj.v17i1.22324

Keywords:

Bauhinia acuminata, antioxidant, cytotoxic and membrane stabilizing

Abstract

The crude methanol extract of leaves of Bauhinia acuminata and its Kupchan fractions were screened for antioxidant, cytotoxic and membrane stabilizing activities. Among all partitionates the aqueous soluble fraction of B. acuminata demonstrated the highest antioxidant activity with IC50 value of 7.22±0.200 ?g/ml. Moreover, the carbon tetrachloride soluble fraction showed significant cytotoxic activity having LC50 value of 12.13±0.215 ?g/ml. On the other hand, in hypotonic solution- and heat- induced conditions, the crude methanol extract inhibited haemolysis of human erythrocyte by 63.94±0.14% and 51.95±0.20%, respectively as compared to 81.97±0.77% and 42.11±0.39% demonstrated by the standard acetyl salicylic acid.

DOI: http://dx.doi.org/10.3329/bpj.v17i1.22324

Bangladesh Pharmaceutical Journal 17(1): 99-101, 2014

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Published

2015-02-21

How to Cite

Khan, M. F., Shilpi, R. I., Rashid, R. B., & Rashid, M. A. (2015). In vitro Antioxidant, Cytotoxic and Membrane Stabilizing Activities of Bauhinia acuminata L. Bangladesh Pharmaceutical Journal, 17(1), 99–101. https://doi.org/10.3329/bpj.v17i1.22324

Issue

Vol. 17 No. 1 (2014)

Section

Articles