Pharmacological Activities of Senna obtusifolia Linn.: A Medicinal Plant of Bangladesh

Authors

  • Md Anisuzzaman Department of Pharmacy, Southern University Bangladesh, Chittagong
  • Md Qamrul Ahsan Department of Pharmacy, Southern University Bangladesh, Chittagong
  • Md Ruhul Kuddus Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad Abdur Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/bpj.v17i2.22338

Keywords:

Senna obtusifolia, anxiolytic, anti-atherothrombosis, membrane stabilizing, alpha amylase

Abstract

The crude methanol extract of seed of Senna obtusifolia Linn. has been investigated for anxiolytic, antiatherothrombosis, membrane stabilizing and alpha-amylase inhibitory activities. The anxiolytic activity was examined in mice by using the hole cross and open field test (OFT). The anti-atherothrombosis activity was evaluated and compared with that of standard streptokinase. The membrane stabilizing activity was tested by using hypotonic solution- and heat-induced hemolysis of human erythrocyte. The plant extract was also assessed for anti-diabetic activity through in vitro ?-amylase inhibitory potential. The ?-amylase inhibitory activity of S. obtusifolia was measured using the starch-iodine method. The crude extract of S. obtusifolia showed moderate anxiolytic activity. In the in-vitro anti-atherothrombosis test, the extract exhibited mild activity as compared to the standard, streptokinase (81.53%). In membrane stabilizing activity test, the plant extract at 1.0 mg/ml inhibited the heat-induced hemolysis of RBCs by 56.37% whereas the standard acetyl salicylic acid (ASA) demonstrated 71.36% inhibition of hemolysis. Our results revealed that the extract produced dose-dependent prevention of digestion of carbohydrates by inhibiting ?-amylase. These findings demonstrated that S. obtusifolia may be a good candidate for further analysis because of its effective pharmacological properties.

DOI: http://dx.doi.org/10.3329/bpj.v17i2.22338

Bangladesh Pharmaceutical Journal 17(2): 182-186, 2014

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Published

2015-02-21

How to Cite

Anisuzzaman, M., Ahsan, M. Q., Kuddus, M. R., & Rashid, M. A. (2015). Pharmacological Activities of Senna obtusifolia Linn.: A Medicinal Plant of Bangladesh. Bangladesh Pharmaceutical Journal, 17(2), 182–186. https://doi.org/10.3329/bpj.v17i2.22338

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Articles