In vitro Cytotoxic, Membrane Stabilizing and Thrombolytic Activities of Polygonum glabrum Willd

Authors

  • Mohammad Firoz Khan Department of Pharmacy, State University of Bangladesh, Dhaka-1205
  • Sikder Nahidul Islam Rabbi Department of Pharmacy, State University of Bangladesh, Dhaka-1205
  • Fahima Aktar Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Hassan Kawsar Department of Pharmacy, State University of Bangladesh, Dhaka-1205

DOI:

https://doi.org/10.3329/bpj.v17i2.22341

Keywords:

Polygonum glabrum, cytotoxic, membrane stabilizing and thrombolytic

Abstract

The crude methanol extract of leaves of Polygonum glabrum Willd and its Kupchan fractions were screened for cytotoxic, membrane stabilizing and thrombolytic activities. Among all fractions, the crude methanol extract showed significant cytotoxic activity having LC50 value 0.74 ± 0.045 ?g/ml. Moreover, in hypotonic solution- and heat- induced conditions, the crude methanol extract inhibited hemolysis of human erythrocyte by 79.21 ± 0.44% and 84.87±0.23%, respectively as compared to 71.9 ± 0.73% and 42.12 ± 0.37% demonstrated by the standard acetyl salicylic acid. On the other hand, in thrombolytic activity assay the methanol extract demonstrated highest clot lysis value of 35.17 ± 0.42%.

DOI: http://dx.doi.org/10.3329/bpj.v17i2.22341

Bangladesh Pharmaceutical Journal 17(2): 202-204, 2014

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Published

2015-02-21

How to Cite

Khan, M. F., Rabbi, S. N. I., Aktar, F., & Kawsar, M. H. (2015). In vitro Cytotoxic, Membrane Stabilizing and Thrombolytic Activities of Polygonum glabrum Willd. Bangladesh Pharmaceutical Journal, 17(2), 202–204. https://doi.org/10.3329/bpj.v17i2.22341

Issue

Vol. 17 No. 2 (2014)

Section

Articles