In vitro and in vivo Antiamoebic Potential of Actinopyga lecanora (Jaeger)

Authors

  • Vijai Lakshmi Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow-226001
  • Sheela Ghosal Divisions of Microbiology, Central Drug Research Institute, Lucknow-226001

DOI:

https://doi.org/10.3329/bpj.v18i2.24308

Keywords:

Anti-amoebic activity, Actinopyga lecanora (Jaeger), Entamoeba histolytica

Abstract

Human amoebiasis, due to Entamoeba histolytica infection, is mainly associated with morbidity thus affecting the quality of life and pace of development in the countries with warm climatic conditions. So far, the available drugs provide only symptomatic relief and they are not devoid of side effects. This leads to obtain novel molecules from natural sources having antiamoebic activity. The methanol extract of Actinopyga lecanora (Jaeger) displayed antiamoebic activity. It showed MIC 125 ?g/ml in our in-vitro studies, but when it was tested in rats, it revealed 88% inhibition of trophozoites at the dose of 900 mg/kg body weight against Entamoeba histolytica. Further work is in progress for the isolation and characterization of active molecules.

Bangladesh Pharmaceutical Journal 18(2): 118-120, 2015

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Author Biography

Vijai Lakshmi, Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow-226001



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Published

2015-07-26

How to Cite

Lakshmi, V., & Ghosal, S. (2015). In vitro and in vivo Antiamoebic Potential of Actinopyga lecanora (Jaeger). Bangladesh Pharmaceutical Journal, 18(2), 118–120. https://doi.org/10.3329/bpj.v18i2.24308

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Articles