Pharmacological Investigation on Ethanol Extract of Scindapsus hederaceus Miq.

Abstract

The present study was conducted to evaluate the antipyretic, anti-inflammatory and membrane stabilizing, antioxidant, thrombolytic, anti-diarrheal activities of Scindapsu shederaceus belonging to the Araceae family. In antipyretic test, temperature reduced from 101.53^°F to 99.86^°F (p<0.05), 99.20^°F (p<0.05) and 99.06^°F (p<0.05) in 1^st, 2^nd and 3^rd hour, respectively and caused maximum reduction of temperature in 1^st hour. In the hot plate method, the extract increased the reaction time of heat sensation significantly to 14.32 seconds. In in vitro anti-inflammatory test, the extract significantly inhibited protein denaturation by 85.17% at 500 ?g/ml, 71.72% at 250 ?g/ml and by 66.55% at 125 ?g/ml. It also inhibited the hypotonic solution-induced haemolysis by 73.19%, 49.69% and 29.15% at same concentration in membrane stabilizing assay. In DPPH inhibition assay the extract showed maximum % inhibition of 65.5% at 100 ?g/ml. In the assay of thrombolytic activity, the extract showed thrombolytic activity of 14.39%. Amylase inhibitory activity was found to be 22.38% at a concentration 100 ?g/ml. In case of antidiarrheal investigation, the extract reveled total inhibition of defection by 35.30%.

Bangladesh Pharmaceutical Journal 20(1): 85-89, 2017